Efficacy of Topical Nepafenac 0.3% in the Management of Postoperative Cystoid Macular Edema

Figures & data

Table 1 Visual Acuity and Central Macular Thickness Prior to Nepafenac Administration and in the Last Follow-Up in Patients with Acute and Chronic Macular Edema

TYPE of CME	VA Pre LogMAR	VA Post LogMAR	CRT Pre (μm)	CRT Post (μm)
Acute	0,00	0,00	387	349
Acute	0,80	0,40	387	533
Acute	1,80	1,80	387	268
Acute	0,40	0,40	387	318
Acute	0,10	0,10	426	380
Acute	0,44	0,10	601	344
Αcute	0,50	0,30	573	329
Acute	0,80	0,40	388	316
Chronic	0,40	0,10	387	563
Chronic	0,60	0,30	601	413
Chronic	0,70	0,90	423	561
Chronic	0,30	0,16	462	385
Chronic	0,40	0,02	508	344
Chronic	0,50	0,30	666	298
Chronic	0,14	0,00	387	351
Chronic	0,40	0,30	387	383
Chronic	0,46	0,40	387	309
Chronic	0,26	0,26	387	303
Chronic	0,60	0,50	412	284
Chronic	0,50	0,30	481	255
Chronic	0,54	0,40	371	339

Table 2 Mean±Standard Deviations (SD) of Best Corrected Visual Acuity (BCVA) and Central Macular Thickness (CRT) Prior to Nepafenac Administration and in the Last Follow-Up in Patients with Acute and Chronic Macular Edema. Statistical Significance: P<0.05.

	BCVA pre±SD (logMAR)	BCVA post±SD (logMAR)	P-value	CRT pre±SD (μm)	CRT post±SD (μm)	P-value
Total (n=21)	0.49±0.36	0.36±0.42	0.004	450.40±90.74	354.60±81.49	0.004
Acute CME (n=8)	0.58±0.60	0.46±0.66	0.144	449.86±95.09	329.14±34.73	0.018
Chronic CME (n=13)	0.44±0.15	0.30±0.23	0.017	450.69±92.28	368.31±96.59	0.050

Figure 1 Changes in best corrected visual acuity (BCVA) in acute and chronic cystoid macular edema (CME) prior to and after treatment of patients. Statistical significance, P<0.05.

Figure 2 Changes in central retinal thickness (CRT) in acute and chronic cystoid macular edema (CME) prior to and after treatment of patients. Statistical significance, P<0.05.

Figure 3 Patient with acute pseudophakic ME before nepafenac administration and after 4 months therapy. Visual acuity elevated from 0.44 logMAR to 0.30 logMAR, and central macular thickness decreased from 601 μm to 379 μm. Green line represents the same area of the fovea prior to and after therapy in infrared picture, which corresponds to CME improvement.

Figure 4 Patient with chronic CME. CME before nepafenac administration and after 4 months therapy. Visual acuity changed from 0.50 logMAR to 0.30 logMAR, and central macular thickness decreased from 499 μm to 255 μm. Green line represents the same area of the fovea prior to and after therapy in infrared picture, which corresponds to CME improvement.