Clinical, Imaging, Histological and Surgical Aspects Regarding Giant Paraovarian Cysts: A Systematic Review

Figures & data

Table 1 The Reported Cases of Giant POCs (Larger Than 150 Mm)

Authors, Year	Age	Size (mm)	Side	Symptoms	Tumoral Markers	Imaging Methods	Preoperative Diagnosis	Surgical Management	Histopathology
Bayar et al, 2006^Citation26	38	320	R	Pain, IAV, PT	Elevated CA 125	USG, MRI	Abdominal cyst	SOE	Serous papillary cystadenoma
Mukhopadhyay 2006^Citation15	18	400	L	Pain, IAV, PT	–	USG	Left ovarian cyst	CE, SOE	Simple serous cyst
Kostov et al, 2008^Citation29	14	300 R 70 L	B	Pain	–	USG	Abdominal tumor	Bilateral CE, RAE	Serous cystadenoma
Saxena et al, 2008^Citation22	16	300	L	Pain, IAV, PT	–	USG, MRI	Left ovarian cyst	LCE	Serous cystadenoma
Borrás Suñer et al, 2009^Citation30	25	150	R	Pain, vomiting	Normal	USG	Right ovarian torsion	LCE	Serous papillary cystadenoma
Kiseli et al, 2012^Citation11	33	300	R	Pain	Normal	USG, MRI	Mesenteric cyst	CE	Serous papillary cystadenoma
Kandil et al, 2013^Citation31	17	260	L	Pain, IAV, PT	Normal	CT	Left ovarian cyst	CE	Simple serous cyst
Leanza et al, 2013^Citation5	14	300	R	Pain, IAV, PT	Normal	USG	Right ovarian cyst	LCE	Paramesonephric cyst
Katke et al, 2013^Citation12	29	350	L	Pregnancy, pain	–	USG, MRI	Mesenteric cyst	CE	Serous cystadenoma
Sagili et al, 2013^Citation2	25	300 R 400 L	B	Pain, IAV, PT	Normal	USG, CT	Bilateral ovarian cysts	Bilateral CE	Paramesonephric cysts
Asare et al, 2015^Citation16	19	270	L	IAV	–	USG, CT	Abdominal cyst	CE	Paratubal cyst
Erikci et al, 2015^Citation20	14	400	L	IAV, PT	Normal	USG, CT	Abdominal cyst	CE, SE	Serous cystadenoma
Shah et al, 2016^Citation29	16	260	L	Pain, IAV, PT	–	USG, CT	Left ovarian cyst	LCE	Paratubal cyst
Lee et al, 2016^Citation25	17	190	R	PT	Normal	USG, CT	Right ovarian cyst	LCE, SE	Serous papillary cystadenoma
Gorkem et al, 2016^Citation27	27	210	R	Pregnancy, pain, PT	Normal	USG, MRI	Abdominal cyst	CE	Serous cystadenoma
Tsuji et al, 2017^Citation23	25	340	R	Pregnancy, PT	–	USG, MRI	Right ovarian cyst	LCE	Paratubal cyst
Marginean et al, 2018^Citation19	15	170	L	IAV, PT	–	USG, MRI	Left ovarian cyst	LCE	Serous cyst
Shin et al, 2018^Citation32	27	160	R	Pain, IAV, PT	Normal	USG CT	Right ovarian cyst	CE	Serous borderline tumor
Agrawal et al, 2018^Citation10	20	298	R	IAV, PT	Normal	USG CT	Right ovarian cyst	CE	Serous papillary cystadenoma
Skaaf et al, 2019^Citation13	31	360	R	IAV, PT	Normal	USG CT	Right ovarian cyst	LCE	Paratubal cyst
Alpendre et al, 2020^Citation33	31	250	R	Pain, vomiting	–	USG CT	Ovarian cyst torsion	AE	Serous papillary cystadenoma
Atileh et al, 2020^Citation14	32	400	R	IAV, PT	Normal	USG CT	Ovarian cyst	LCE, SE	Serous cystadenoma
Bhansakarya et al, 2020^Citation34	25	270	R	IAV, PT	Normal	USG CT	Ovarian cyst	LCE	Serous cystadenoma
Zvizdic et al, 2020^Citation24	15	250	L	Pain, IAV, PT, constip	Normal	USG, MRI	Left ovarian cyst	CE	Serous cystadenoma
Tjokroprawiro et al 2021^Citation1	30	223	L	IAV, PT	Normal	CT	Left ovarian cyst	CE	Serous benign cyst
Kiran et al, 2021^Citation3	13	230 R 43 L	B	IAV, PT, vaginal bleeding	Normal	USG CT	Adnexal cyst	LCE	Serous cystadenoma
Čančar et al, 2021^Citation35	26	580	R	Pain, IAV, PT, constip, dysuria, uterus prolapse	–	USG CT	Abdominal cyst	CE, SE	Simple serous cyst

Abbreviations: R, right; L, left; B, bilateral; IAV, increased abdominal volume; PT, palpable tumor; constip, constipation; USG, ultrasonography; CT, computed tomography; MRI, magnetic resonance imaging; SOE, salpingo-oophorectomy; HE, hysterectomy; LCE, laparoscopic cystectomy; SE, salpingectomy; CE, cystectomy; RAE, right anexectomy; AE, adnexectomy.

Figure 1 PRISMA flow diagram of the selection process.

Notes: PRISMA figure adapted from: Page MJ, McKenzie JE, Bossuyt PM et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. Creative Commons CC BY 4.0 license²¹.

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