The Changes of Thyroid Function and Related Factors in Critical Patients without Thyroid Illness in ICU: A Retrospective Cross-Sectional Study

Figures & data

Table 1 Comparison of Clinical Data, Thyroid Function and Laboratory Examination of the Two Groups

	CH Group (n=21)	LT3S Group (n=31)	t/z/x^2	P
Clinical data
Age (Years old)	64.4 ± 10.5	64.6 ± 13.5	−0.062	0.951
Gender (Female), n (%)	16/21(76.2%)	25/31(80.6%)	0.149	0.700
APACHE II score	20.6 ± 3.6	19.3 ± 3.6	1.201	0.235
Systolic blood pressure (mmHg)	131.6 ± 20.1	124.7 ± 23.5	1.094	0.279
Diastolic blood pressure (mmHg)	77.9 ± 17.6	72.1 ± 15.6	1.248	0.218
Basic disease
Diabetes mellitus	2/21(9.5%)	4/31(12.9%)	0.000	> 0.999
Hypertension	6/21(28.6%)	8/31(25.8%)	0.047	0.852
Organic heart disease	3/21(14.3%)	1/31(3.2%)	0.880	0.348
Cancer	3/21(14.3%)	0/31(0.0%)	–	0.060
Tracheotomy	5/21(23.8%)	5/31(17.2%)	0.046	0.830
Choice of treatment therapy
Use of vasoactive drugs (Yes/No)	9/21(42.8%)	13/31(41.9%)	0.000	> 0.999
Taking corticosteroids (Yes/No)	6/21(28.6%)	5/31(16.1%)	0.536	0.464
Taking glucose solution (Yes/No)	0/21(0.0%)	0/31(0.0%)	0.000	> 0.999
Thyroid function 24h after admission
TSH (IU/mL)	0.3 ± 0.3	1.7 ± 0.9	−6.116	< 0.001*
RT3 (ng/mL)	0.6 ± 0.1	1.8 ± 0.3	−16.581	< 0.001*
FT3 (pmol/L)	2.1 ± 0.6	2.3 ± 0.7	−1.177	0.245
FT4 (pmol/L)	14.6 ± 5.3	13.3 ± 4.5	0.919	0.362
Laboratory examination
HbA1c level	8.1 ± 2.1	6.1 ± 1.7	3.782	< 0.001*
White blood cell count	10.7 ± 6.4	10.6 ± 4.4	0.075	0.940
Blood platelet count	176.7 ± 142.0	204.8 ± 96.5	−0.851	0.399
CRP	101.2 ± 77.8	181.9 ± 510.0	−0.717	0.477
FPG	10.3 ± 5.0	6.8 ± 2.5	3.223	0.002*
TG	1.6(1.2–2.4)	1.25(0.9–1.7)	−1.939	0.052
CHOL	3.6 ± 1.3	3.4 ± 1.3	0.580	0.563
HDL	0.9 ± 0.4	0.9 ± 0.4	0.191	0.850
LDL	1.8 ± 1.2	1.8 ± 1.0	−0.088	0.930

Notes: *P < 0.05, the difference is statistically significant. Data are presented as mean ± standard error, median (interquartile range) and ratio (n%).

Abbreviations: CH group, central hypothyroidism; LT₃S group, low T₃ syndrome group; CRP, C-reactive protein; FPG, fasting plasma glucose; TG, triglyceride; CHOL, cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HbA1c, glycated hemoglobin.

Figure 1 (A) Fasting blood plasma glucose level was negatively correlated with serum thyroid-stimulating hormone level; (B) fasting blood plasma glucose level was negatively correlated with serum reverse triiodothyronine level; (C) fasting blood plasma glucose level was not associated with serum free triiodothyronine level; (D) fasting blood glucose level was not associated with serum free tetraiodothyronine level.

Figure 2 With fasting plasma glucose as the variable and central hypothyroidism as the grouped variable, the receiver operating characteristic curve was created and the area under the curve was calculated as being 0.78.