Cumulative Doses Predict the Risk of Furosemide-Induced Electrolyte Abnormalities in Critically Ill Neonates

Figures & data

Table 1 Demographic Characteristics of the Study Participants (N = 90)

Variables	Values
Gestational age (weeks)	29 (23–39.7)
Gestational age categories (n)
Term	14
Late preterm	17
Very preterm	28
Extremely preterm	31
Male: Female (n)	57: 33
Birthweight (kg)	1.2 (0.54–5.3)
Birthweight categories (n)
Normal	17
Low	16
Very low	26
Extremely low	31
Length (cm)	38 (28–58)
APGAR score
First minute	7 (1–9)
Fifth minute	9 (1–10)
Tenth minute	10 (2–10)
Duration of stay (days)	45 (7–140)
Alive: Dead (n)	82: 8

Note: All the values are represented in median (range) unless specified.

Figure 1 Correlation between gestational age and cumulative furosemide doses. The observations are represented by blue circles. The diagonal line represents the line of best fit.

Figure 2 Cumulative furosemide doses according to gestational age categories. The boxplots represent the cumulative doses administered in each gestational age categories. The two horizontal lines above and below the boxes represent the upper and lower limit of ranges. The asterisk points represents the extreme values.

Figure 3 Cumulative furosemide dose adjusted to body-weight according to gestational age categories. The boxplots represent the cumulative dose adjusted to body-weight administered in each gestational age categories. The two horizontal lines above and below the boxes represent the upper and lower limit of ranges. The asterisk points represents the extreme values.

Figure 4 Furosemide dose per kilogram body weight according to gestational age categories. The boxplots reveal the daily per kilogram dose of furosemide in the study participants. The two horizontal lines above and below the boxes represent the upper and lower limit of ranges. The circles and asterisk points represents the extreme values.

Table 2 Baseline Clinical and Laboratory Parameters of the Study Participants (N = 90)

Parameters	Values
Urine output (mL/day)	113 (44–331)
Body weight (kg)	1.2 (0.5–5.3)
Serum creatinine (mmol/L)	64 (19–182)
Serum sodium (mmol/L)	141 (127–161)
Serum potassium (mmol/L)	4.4 (2.9–6.2)
Serum chloride (mmol/L)	105 (82–116)
Serum bicarbonate (mmol/L)	23 (15–36)
Serum calcium (mmol/L)	2 (1.1–2.9)
Serum magnesium (mmol/L)	0.7 (0.4–3.2)

Note: All the values are represented in median (range).

Figure 5 Percent changes in the clinical and laboratory parameters from baseline. The individual observations are represented by the colored circles.

Figure 6 ROC curve for predictive accuracy of the cumulative furosemide doses with electrolyte disturbances. The green diagonal line is the reference line, and the blue line indicates the area for the predictive ability of cumulative dose for electrolyte disturbances.