The Use of Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio and Platelets-to-Lymphocyte Ratio in the Assessment of the Risk of Conversion and Complications After Cholecystectomy Performed Due to Symptomatic Cholelithiasis

Figures & data

Table 1 Clinical Characteristics of the Analyzed Population

Variable		Total = 227
Gender	Men	61 (26.9%)
	Women	166 (73.1%)
Age	Mean	54.9
	Median	58
Type of admission	Elective	206 (90.8%)
	Emergency	21 (9.2%)
ASA grade	I	34 (15.0%)
	II	171 (75.3%)
	III	22 (9.7%)
	IV	0
	V	0
Conversion occurrence	No	199 (87.7%)
	Yes	28 (12.3%)
Duration of the procedure (minutes)	Mean	76.3
	Median	70
Length of hospitalization (days)	Median	2
The grade of postoperative complications according to the Clavien-Dindo scale	0	166 (73.1%)
	I	27 (11.8%)
	II	26 (11.5%)
	III	8 (3.5%)
	IV	0
	V	0

Table 2 NLR, MLR and PLR Values in the Analyzed Population

Variable	Total (N=227)			Men (N=61)			Women (N=166)			P value
	Mean	Median	Min-max	Mean	Median	Min-max	Mean	Median	Min-max
NLR	2.89	2.15	0.48 30.50	2.67	2.12	0.71 18.60	2.98	2.16	0.48 30.50	0.44
MLR	0.27	0.22	0.05 1.50	0.27	0.21	0.08 1.30	0.26	0.22	0.05 1.50	0.89
PLR	134.89	124.00	58.07 518.89	128.71	119.38	58.06 303.90	137.16	124.52	59.52 518.89	0.29

Abbreviations: P, statistical significance level; min-max, minimum-maximum range; NLR, neutrophil-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio; PLR, platelets-to-lymphocyte ratio.

Table 3 Spearman Correlation Analysis Between Quantitative Variables and NLR, MLR and PLR Values in the Study Population

Variable	Age	Duration of the Procedure (Minutes)	Length of Hospitalization (days)
	rS
NLR	0.018	0.130	0.226
MLR	0.131	0.064	0.247
PLR	0.027	0.099	0.181

Abbreviations: rs, Spearman’s rank correlation, NLR, neutrophil-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio; PLR, platelets-to-lymphocyte ratio.

Table 4 NLR, MLR and PLR Values Depending on the Occurrence of Conversion

Variable	Total (N=227)			Group Without Conversion (N=199)			Group with Conversion (N=28)			P value
	Mean	Median	Min-max	Mean	Median	Min-max	Mean	Median	Min-max
NLR	2.89	2.15	0.48 30.50	2.41	2.10	0.48 9.70	6.31	3.05	1.06 30.50	0.0005
MLR	0.27	0.22	0.045 1.50	0.23	0.21	0.05 0.90	0.49	0.31	0.08 1.50	0.0002
PLR	134.89	124.00	58.07 518.89	128.36	122.50	58.06 334.55	181.27	141.42	73.20 518.89	0.001

Abbreviations: P, statistical significance level; min-max, minimum-maximum range; NLR, neutrophil-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio; PLR, platelets-to-lymphocyte ratio.

Table 5 The Relationship Between the Grade of Postoperative Complications and the NLR, MLR and PLR Values

Variable	The Grade of Complications in the Clavien-Dindo Scale												P value
	0 (N=166)			I (N=27)			II (N=26)			III (N=8)
	Mean	Median	Min-Max	Mean	Median	Min-Max	Mean	Median	Min-Max	Mean	Median	Min-Max
NLR	2.30	2.01	0.48 8.15	2.37	2.20	1.00 4.17	6.37	3.58	1.06 30.50	5.65	3.68	1.54 19.50	0.0001
MLR	0.23	0.21	0.05 0.62	0.24	0.23	0.11 0.44	0.47	0.33	0.06 1.50	0.45	0.37	0.15 1.30	0.008
PLR	128.54	122.03	58.06 334.55	137.47	132.00	76.39 282.73	166.02	137.33	68.85 518.89	156.57	118.24	99.34 303.86	0.2253

Abbreviations: P, statistical significance level; min-max, minimum-maximum range; NLR, neutrophil-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio; PLR, platelets-to-lymphocyte ratio.

Figure 1 The relationship between the grade of postoperative complications and the NLR value.

Figure 2 The relationship between the grade of postoperative complications and the MLR value.

Figure 3 The relationship between the grade of postoperative complications and the PLR value.