Active axial spondyloarthritis: potential role of certolizumab pegol

Figures & data

Table 1 Modified New York Criteria for Ankylosing Spondylitis

Clinical criteria

• Low back pain and stiffness which improves with activity for more than three months

• Limited range of motion of the lumbar spine in both forward and lateral bending.

• Limitation of chest expansion relative to normal values correlated for age and sex

Radiological criteria

• Sacroiliitis grade ≥2 bilaterally

• Sacroiliitis grade 3 to 4 unilaterally

Note: Diagnosis of AS is made if the patient fulfills at least one radiological and one clinical criteria. Source: Copyright © 1984 American College of Rheumatology. van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984;27(4):361–368.²⁴

Table 2 ASAS classification criteria for axial spondyloarthritis (SpA)

In patients with ≥ 3 months back pain and age at onset < 45 years
Sacroiliitis on imaging^A Plus ≥1 SpA feature^B	OR	HLA-B27 Plus ≥2 other SpA features^B
A. Sacroiliitis on imaging		B. SpA features
• Active (acute) inflammation on MRI highly suggestive of sacroiliitis associated with SpA		• Inflammatory back pain
		• Arthritis
		• Enthesitis (heel)
• Definite radiographic sacroiliitis according to modified New York criteria		• Uveitis
		• Dactylitis
		• Psoriasis
		• Crohn’s/ulcerative colitis
		• Good response to NSAIDS
		• Family history of SpA
		• HLA-B27 positivity
		• Elevated CRP

Notes: Reproduced from The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Rudwaleit M, van der Heijde D, Landewe R, et al. Ann Rheum Dis. 68(6):777–783. Copyright © 2009. With permission from BMJ Publishing Group.³

Abbreviations: ASAS, Assessment of SpondyloArthritis International Society; CRP, C-reactive protein; MRI, magnetic resonance imaging; NSAIDs, non-steroidal anti-inflammatory drugs.³

van der LindenSValkenburgHACatsAEvaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteriaArthritis Rheum19842743613686231933

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RudwaleitMvan der HeijdeDLandeweRThe development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selectionAnn Rheum Dis200968677778319297344

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