Subfoveal choroidal thickness after photodynamic therapy in patients with acute idiopathic central serous chorioretinopathy

Figures & data

Table 1 Baseline demographic characteristics

	PDT group (n=31)	Control group (n=32)	P-value
Age (years)
Mean ± SD	45.63±6.24	47.24± 5.9	0.68
Range	28–67	22–69
Sex
Male to female	26:5	27:5	0.78
Spherical equivalent refractive error (diopters)
Mean ± SD	−1.69±2.24	−2.54±1.96	0.02
Range	−3.50 to 2.75	−3.75 to 2.75
Interval between onset of symptoms and treatment (weeks)
Mean ± SD	45.74±22.85	–	–
Range	28–62	–	–

Abbreviations: PDT, photodynamic therapy; SD, standard deviation.

Figure 1 The changes of subfoveal choroidal thickness after photodynamic therapy.

Table 2 Subfoveal choroidal thickness at baseline

	PDT group			Control group (n=64)
	Symptomatic eyes (n=31)	Fellow eyes with hyperfluorescence in ICGA (n=23)	Fellow eyes with hyperfluorescence in ICGA (n=8)
Mean ± SD	422±132	446±105	279±115	274±53
Range	136–642	331–642	136–372	97–335

Notes: Among-group comparison using Student’s independent or paired t-tests. P-values<0.05 are considered to be statistically significant.

Abbreviations: ICGA, indocyanine green angiography; PDT, photodynamic therapy; SD, standard deviation.

Table 3 Subfoveal choroidal thickness during follow-up

	PDT group (symptomatic eyes, n=31)	PDT group (fellow eyes, n=31)
Choroidal thickness at baseline (μm)
Mean ± SD	422±132	367±114
Range	136–642	113–573
Three days follow-up (μm)
Mean ± SD	478±163	371±123
Range	157–668	121–569
Four weeks follow-up (μm)
Mean ± SD	362±113	368±134
Range	112–574	108–581
Twelve weeks follow-up (μm)
Mean ± SD	339±135	368±121
Range	108–578	115–575

Notes: Among-group comparison using Student independent or paired t-tests. P-values<0.05 were considered to be statistically significant.

Abbreviations: PDT, photodynamic therapy; SD, standard deviation.

Figure 2 Case 1, a 36-year-old man with blurred vision in his right eye. (A) A fundus photograph of the right eye showing a serous retinal detachment at the fovea. (B) Fundus photograph of the left eye is normal. (C and D) ICGA showed bilateral choroidal vascular hyperpermeability in middle-phase. The subfoveal choroidal thickness at the baseline was 452 μm in the right eye and 351 μm in the left eye. (E and F) After PDT, the subfoveal choroidal thickness in his right eye decreased to 370 μm at week 4. However, the subfoveal choroidal thickness in the left eye increased to 494 μm, with ICGA indicating aggravation of his choroidal vascular hyperpermeability. (G and H) At week 11, in his left eye, ICGA showed aggravation of choroidal vascular hyperpermeability in middle-phase, with a subfoveal choroidal thickness of 470 μm.

Abbreviations: ICGA, indocyanine green angiography; PDT, photodynamic therapy.