Colchicine intoxication: a report of two suicide cases

Figures & data

Table 1 Blood gas monitoring for case 1

	pH	pCO2	pO2	HCO3	BE	AG
On admission	7.372	41.6	49.2	23	−1.2	12
12 hours	7.391	23.0	65.3	13.7	−9.1	21
24 hours	7.464	23.6	53.4	16.7	−6.4	16
36 hours	7.341	42.0	36.4	20.5	−3.1	15
42 hours	7.225	42.2	30.6	15.0	−10.4	20
48 hours	7.415	31.0	46.9	20.8	−3.7	21
55 hours	6.665	76.0	43.1	5.2	−26.0	30

Abbreviations: AG, anion gap; BE, base excess; HCO₃, bicarbonate; pCO₂, partial pressure of carbon dioxide; pO₂, partial pressure of oxygen.

Table 2 Complete blood count, coagulation tests, and biochemistry measurements for case 1

	PT (sec)	INR	aPTT (sec)	AST (U/L)	ALT (U/L)	LDH (U/L)	Total-CK (U/L)	CK-MB (U/L)	PLTs (/mm^3)	Trop I (ng/mL)
On admission	27.7	2.27	27.7	87	19	1,568	116	45	250,000	0.39
12 hours	36.3	3.09	45.2	174	24	2,905	602	117	209,000	5.47
24 hours	34.4	2.91	43.2	233	30	3,650	704	125	138,000	7.70
36 hours	40.2	3.47	67.9	297	36	4,940	1,874	195	113,000	16.32
42 hours	66.7	6.18	157.3	561	93	6,105	1,415	135	73,000	34.04

Abbreviations: ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; CK-MB, creatine kinase myocardial band; INR, international normalized ratio; LDH, lactate dehydrogenase; PLTs, platelets; PT, prothrombin time; Total-CK, total creatine kinase; Trop I, troponin I.

Table 3 Blood gas monitoring for case 2

	pH	pCO2	pO2	HCO3	BE
On admission	7.48	21.2	49.4	20	−5.9
12 hours	7.369	31.7	54.1	19.1	−6.1
24 hours	7.44	26.0	74.8	20.5	−5.6
36 hours	7.448	26.0	74.4	20.6	−4.6
42 hours	7.418	26.2	104	19.3	−6.3
48 hours	7.433	32.1	45.0	22.7	−2.5
72 hours	7.395	35.6	64.8	22.2	−2.1

Abbreviations: BE, base excess; HCO₃, bicarbonate; pCO₂, partial pressure of carbon dioxide; pO₂, partial pressure of oxygen.

Table 4 Complete blood count, coagulation tests, and biochemistry measurements for case 2

	PT (sec)	INR	AST (U/L)	ALT (U/L)	LDH (U/L)	Total-CK (U/L)	CK-MB (U/L)	PLTs (/mm^3)	Trop I (ng/mL)
On admission	15.1	1.14	32	21	156	112	25	428,000	0.00
12 hours	18.4	1.42	48	26	147	602	117	417,000	0.01
24 hours	21.9	1.73	52	32	187	147	37	352,000	0.00
36 hours	18.7	1.45	50	35	175	141	37	388,000	0.00
48 hours	16.3	1.24	26	23	214	99	40	325,000	0.01
72 hours	12.7	0.93	24	36	234	63	21	304,000	0.03

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CK-MB, creatine kinase myocardial band; INR, international normalized ratio; LDH, lactate dehydrogenase; PLTs, platelets; PT, prothrombine time; Total-CK, total creatin kinase; Trop I, troponin I.