The impact of intrahepatic cholestasis of pregnancy with hepatitis B virus infection on perinatal outcomes

Figures & data

Table 1 General clinical condition of the four groups

Groups	n	Weight (kg)	Age (years)	Gestational age (weeks)
Control	50	66.4±5.2	28.2±5.8	39.2±0.9
ICP	50	64.7±6.8	27.7±6.1	38.9±0.7
HBV	50	65.4±6.5	26.3±6.4	38.2±1.2
ICP with HBV	50	61.5±7.6	26.8±7.1	37.4±1.6

Abbreviations: HBV, hepatitis B virus; ICP, intrahepatic cholestasis of pregnancy.

Table 2 Methods of childbirth in each group

Groups	n	PROM, MSAF	Cesarean section	Eutocia
Control	50	3 (6.0)	8 (16.0)	42 (84.0)
ICP	50	13 (26.0)*	37 (74.0)*	12 (24.0)
HBV	50	11 (22.0)**	16 (32.0)**	32 (64.0)
ICP with HBV	50	26 (52.0)***	47 (94.0)***	4 (8.0)

Notes: All numbers are n (%);

* P<0.05, ICP group vs control group;

** P<0.05, HBV group vs control group;

*** P<0.05, IPC with HBV group vs control group.

Abbreviations: HBV, hepatitis B virus; ICP, intrahepatic cholestasis of pregnancy; MSAF, meconium-stained amniotic fluid; PROM, premature rupture of membranes.

Table 3 The rates of HBV infection in infants

Groups	n	HBV infection
		(+)	(−)
Control	50	0 (0)	50 (100)
ICP	50	0 (0)	50 (100)
HBV	50	5 (10)	45 (90)
ICP with HBV	50	28 (56)*	22 (44)

Notes: All numbers are n (%);

* P<0.05, ICP with HBV group vs other groups.

Abbreviations: HBV, hepatitis B virus; ICP, intrahepatic cholestasis of pregnancy.

Table 4 The rate of fetal distress in the four groups

Groups	n	Rate of fetal distress
Control	50	3 (6)
ICP	50	13 (26)
HBV	50	7 (14)
ICP with HBV	50	30 (60)*

Notes: All numbers are n (%);

* P<0.05, ICP with HBV group vs other groups.

Abbreviations: HBV, hepatitis B virus; ICP, intrahepatic cholestasis of pregnancy.

Table 5 Infant Apgar scores in the four groups

Groups	n	Apgar scores
		0–3	4–7	>7
Control	50	0 (0)	2 (4)	48 (96)
ICP	50	2 (0)	4 (8)	44 (92)
HBV	50	1 (2)	6 (12)	43 (86)
ICP with HBV	50	10 (20)*	16 (32)*	24 (48)

Notes: All numbers are n (%);

* P<0.05, ICP with HBV group vs other groups.

Abbreviations: HBV, hepatitis B virus; ICP, intrahepatic cholestasis of pregnancy.

Table 6 The rate of birth defects in the four groups

Groups	n	Rate of birth defect
Control	50	0 (0)
ICP	50	0 (0)
HBV	50	1 (2)
ICP with HBV	50	8 (16)*

Notes: All numbers are n (%);

* P<0.05, ICP with HBV group vs other groups.

Abbreviations: HBV, hepatitis B virus; ICP, intrahepatic cholestasis of pregnancy.