Managing infertility with the follitropin alfa prefilled pen injector – patient considerations

Figures & data

Figure 1 Relation of frequency of OHSS and the use of recombinant hFSH.

Notes: r-hFSH was introduced into the market in Germany in 1998. Data from the German IVF-Registry – D·I·R; www.deutsches-ivf-register.de.³³
Abbreviations: FSH, follicle stimulating hormone; OHSS, ovarian hyperstimulation syndrome; r-hFSH, recombinant-human follicle stimulating hormone.

Figure 2 Significant milestones in gonadotropin development.

Notes: The more the gonadotropins are purified, the higher is the specific activity and consistency, providing a greater safety for the patients. In green: urinary products still on the market; in blue: recombinant gonadotropins up to filled by mass; in black: newer recombinant preparations and the future.
Abbreviations: FbM, filled by mass; hp, highly purified; Gn, gonadotropin; rec-h(FSH+LH), fixed combination of recombinant FSH and recombinant LH in the ratio 2:1: Pergoveris^® (Merck Senoro, Darmstadt, Germany); FSH, follicle stimulating hormone; LH, leutinizing hormone; hMG, urinary human menopausal gonadotropin; hCG, human chorionic gonadotropin; PMSG, pregnant mare serum gonadotropin; rec, recombinant.

DIR Deutsches IVF Register [homepage on the Internet] Available from: www.deutsches-ivf-register.deAccessed April 4, 2015 German

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