Effectiveness and safety of Humalog Mix 50/50 versus Humalog Mix 75/25 in Chinese patients with type 2 diabetes

Figures & data

Figure 1 Flow chart showing patient disposition.

Table 1 Patient characteristics in each group

	Group A	Group B
Number of patients (of 146 total)	73	73
Number of males/females	38/35	40/33
Age range (years)	39–72	45–76
Mean ± SD age (years)	57.8±2.2	59.2±2.5
Mean BMI	24.83	24.79
Duration of illness range (years)	1–14	3–15
Mean ± SD duration of illness (years)	5.6±1.5	5.8±1.7
Mean ± SD pre-treatment FBG (mmol/L)	8.9±1.8	8.7±1.7
Mean ± SD pre-treatment P2hBG (mmol/L)	11.7±1.8	11.6±1.8
Mean ± SD pre-treatment HbA1c (%)	9.7±1.5	10.1±1.6

Abbreviations: BMI, body mass index; FBG, fasting blood glucose; HbA_1c, glycosylated hemoglobin; P2hBG, 2-hour postprandial blood glucose; SD, standard deviation.

Table 2 Insulin dose titration algorithm

Range of FBG or pre-dinner SMBG (mg/dL) (mmol/L)		Insulin dose adjustment
<80	<4.4	−2 U
80–110	4.4–6.1	–
111–140	6.2–7.8	+2 U
141–180	7.83–10	+4 U
>180	>10	+6 U

Abbreviations: SMBG, self-monitoring of blood glucose; FBG, fasting blood glucose.

Table 3 FBG, P2hBG, and HbA_1C levels prior to and after treatment in the two groups

	FBG (mmol/L)		P2hBG (mmol/L)		HbA1C (%)
	Pre-treatment	Post-treatment	Pre-treatment	Post-treatment	Pre-treatment	Post-treatment
Group A	8.9±1.8	6.3±1.3*Δ	11.7±1.8	7.5±1.3*Δ	9.7±1.5	5.5±1.4*Δ
Group B	8.7±1.7	7.6±1.5	11.6±1.8	9.6±1.5	10.1±1.6	6.5±1.5

Notes: Data are shown as the mean ± standard deviation.

* Statistically significant (compared with pre-treatment), P<0.05. Δ indicates statistical significance compared with group B, P<0.05.

Abbreviations: FBG, fasting blood glucose; HbA_1c, glycosylated hemoglobin; P2hBG, 2-hour postprandial blood glucose.

Table 4 Hypoglycemia

	Humalog Mix 50/50		Humalog Mix 75/25
	n (%)	Event	n (%)	Event
Number	7	3	7	3
Minor	5 (6.84%)	5	4 (5.48%)	6
Major	0		0
Nocturnal	0		2 (2.74%)	2

Table 5 Insulin dose at the end of the study (U/kg)

	Humalog Mix 50/50		Humalog Mix 75/25
	Pre-breakfast	Pre-dinner	Pre-breakfast	Pre-dinner
Mean (SD)	0.45±0.14	0.47±0.16	0.46±0.15	0.48±0.17
Ratio	49%	51%	51%	49%
Total daily dose, mean (SD)	0.84±0.31 U/kg		0.87±0.27 U/kg

Abbreviation: SD, standard deviation.