Combination of tadalafil and finasteride for improving the symptoms of benign prostatic hyperplasia: critical appraisal and patient focus

Figures & data

Table 1 Comparison of treatment results for LVID study

Treatment	I-PSS	IIEF-EF	Qmax (mL/sec)
Tadalafil versus placebo	−2.1	4.0	2.4
Tamsulosin versus placebo	−1.5	−0.4	2.2

Abbreviations: I-PSS, International Prostate Symptom Score; IIEF-EF, International Index of Erectile Function-erectile function domain; Q_max, maximum flow rate.

Table 2 Comparison of year 4 treatment results for MTOPS study

Treatment	I-PSS	Qmax (mL/sec)
Placebo	−4.0	1.4
Doxazosin	−6.0	2.5
Finasteride	−5.0	2.2
Combination doxazosin/finasteride	−7.0	3.7

Abbreviations: I-PSS, International Prostate Symptom Score; MTOPS, Medical Therapy of Prostatic Symptoms; Q_max, maximum flow rate.

Figure 1 Comparison of treatment results with regard to I-PSS scores reported by Casabé et al.²⁵

Abbreviations: I-PSS, International Prostate Symptom Score; LS, least squares; SE, standard error; PBO, placebo; FIN, finasteride; TAD, tadalafil; LSTD, least squares treatment difference.

Notes: ^‡Indicates P≤0.001; ^#Indicates P<0.05. Reprinted from the Journal of Urology; 191(3); Casabé A, Roehrborn CG, Da Pozzo LF, et al; Efficacy and safety of the coadministration of tadalafil once daily with finasteride for 6 months in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia; 727–733. Copyright © 2014, with permission from Elsevier.²⁵

Figure 2 Comparison of treatment results with regard to IIEF scores reported by Glina et al.²⁷

Notes: (A) IIEF domains in men with baseline erectile dysfunction. (B) IIEF domains in men without baseline erectile dysfunction. (A and B) Question 3 related to vaginal penetrative ability. Question 4 related to erection maintenance. Figure reproduced with permission from John Wiley and Sons, from Glina S, Roehrborn CG, Esen A, et al. Sexual function in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia: results of a 6-month, randomized, double-blind, placebo-controlled study of tadalafil coadministered with finasteride. Journal of Sexual Medicine. 2015;12(1):129–138. Copyright © 2014 International Society for Sexual Medicine.
Abbreviations: IIEF, International Index of Erectile Function; LS, least squares.

CasabéARoehrbornCGDa PozzoLFEfficacy and safety of the coadministration of tadalafil once daily with finasteride for 6 months in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasiaJ Urol2014191372773324096118

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GlinaSRoehrbornCGEsenASexual function in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia: results of a 6-month, randomized, double-blind, placebo-controlled study of tadalafil coadministered with finasterideJ Sex Med201512112913825353053

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