GLP-1 reduces metalloproteinase-9 induced by both hyperglycemia and hypoglycemia in type 1 diabetes. The possible role of oxidative stress

Figures & data

Figure 1 MMP-9 and plasma 8-iso PGF2α variations during acute hypoglycemia (A) and acute hyperglycemia (B), with or without GLP-1.

Notes: (A) Glycemia, 8-iso-PGF2α, and MMP-9 in type 1 diabetes (n=15) during hypoglycemia and hypoglycemia plus GLP-1 infusion. White triangle: hypoglycemia; black triangle: hypoglycemia + GLP-1; *P<0.01 vs basal; ^#P<0.01 vs hypoglycemia + GLP-1. (B) Glycemia, 8-iso-PGF2α, and MMP-9 in type 1 (n=15) diabetes during hyperglycemia and hyperglycemia plus GLP-1 infusion. White circle: hyperglycemia; black circle: hyperglycemia + GLP-1; *P<0.01 vs basal; ^#P<0.01 vs hyperglycemia + GLP-1. Copyright © American Diabetes Association. From Diabetes Care^®, Vol 36, 2013; 2346–2350. Reprinted with permission from The American Diabetes Association.⁸

CerielloANovialsAOrtegaEGlucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetesDiabetes Care20133682346235023564922

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