A case series of pregnancy- and lactation-associated osteoporosis and a review of the literature

Figures & data

Table 1 Background information of case 1 and case 2 ahead of this study

Variable (unit)	Reference value	Case 1	Case 2
Age (years)		31	37
BMI (kg/m^2)		22.2	21.6
1,25(OH)2 D (pg/mL)	20–60	35.6	37.6
25(OH)D (ng/mL)	7–41	27	27
ucOC (ng/mL)	<4.5	28.1	6.33
u-NTX (pmol/mmol)	9.3–54.3	58	59
BAP (U/L)	9.6–35.4	42.6	37.4
AL-P (IU)	110–360	358	217
Corrected Ca (mg/dL)	8.6–10.1	8.8	8.8
P (mg/dL)	2.5–4.6	3.7	3.9

Notes: Only ucOC in case 1 was measured at 4 months after treatment. All of the data in case 2 were measured at 1 month after treatment with alfacalcidol. Serum Ca was corrected by albumin.

Abbreviations: BMI, body mass index; BAP, bone alkaline phosphatase; ucOC, undercarboxylated osteocalcin; u-NTX, urinary NTX; AL-P, alkaline phosphatase; P, phosphorous.

Table 2 Changes in BMD values

BMD value	Case 1	Case 2
L-BMD (g/cm^2)	0.675	0.662
L-BMD (SD)	−3.6	−3.7
L-BMD after 6 years of treatment (g/cm^2)	0.992	0.855
IR of L-BMD after 6 years of treatment	36.6%	29.2%
H-BMD (g/cm^2)	0.768	0.794
H-BMD (SD)	−1.4	−1.2
H-BMD after 6 years of treatment (g/cm^2)	0.841	0.896
IR of H-BMD after 6 years of treatment	9.5%	12.8%

Abbreviations: BMD, bone mineral density; H-BMD, hip BMD; IR, increasing rate; L-BMD, lumbar BMD; SD, standard deviation.

Table 3 Changes of u-NTX and ucOC level at each time point before and after treatment

	0	4 m	10 m	2 y	4 y	5 y
Case 1
u-NTX (pmol/mmol)	58	60.6	59.1	41.4	43.6	33.9
ucOC (ng/mL)		28.1	7.03	5.9	5.72	3.91
Case 2
u-NTX (pmol/mmol)	37.6	31		15.3	24.5	26.8
ucOC (ng/mL)	6.33	3.11		1.49	1.7	1.97

Note: The variables (0, 4 m, 10 m, 2 y, 4 y, and 5 y) are time points at which the researchers examined bone markers.

Abbreviations: ucOC, undercarboxylated osteocalcin; u-NTX, urinary NTX; y, year; m, month.