Comparison of propofol–hydromorphone and propofol–dexmedetomidine in patients with intubation after maxillofacial plastic surgery

Figures & data

Table 1 General information of patients in the two groups

Group	Sex (M/F)	Age (years)	Body weight (kg)	Blood loss (mL)	Surgery time (min)	Anesthesia time (min)
P–H group	8/13	23.1±3.4	56.8±8.9	459.5±167.0	237.6±64.9	284.5±55.8
P–D group	10/11	20.2±2.4	55.9±6.5	421.4±148.8	206.2±81.3	253.8±83.6

Abbreviations: P–D, propofol plus dexmedetomidine; P–H, propofol plus hydromorphone.

Table 2 Physiology indices at different time-points in the two groups

Group	T0	T1	T2	T3	T4	T5	T6
MAP (mmHG)
P–H group	74.5±10.3	72.0±9.5	71.6±11.1	72.3±9.4	69.7±6.4	69.1±7.8	72.1±6.4
P–D group	79.5±10.5	75.6±11.6	72.9±11.7	71.8±9.6	66.7±9.0	66.0±8.5	66.2±8.2
RR (time/min)
P–H group	12.8±2.5	12.2±1.6	12.2±2.2	12.1±2.5	13.8±3.4	13.0±3.3	14.8±2.2
P–D group	12.6±2.4	12.6±2.6	13.3±2.2	13.0±2.5	14.7±3.5	15.0±2.8	16.5±3.2
HR (time/min)
P–H group	66.2±10	66.9±9.3	69.0±12.3	70.9±12.2	78.0±11.0#	79.8±11.0#	88.1±9.2#
P–D group	69.4±10.7	66.6±9.0	65.3±10.1	64.0±12.2	65.5±12.8	64.7±10.2	71.3±10.7

Notes:

# P<0.05 vs P–D group. There were two patients in the P–D group who demonstrated sinus bradycardia with HR <50 bpm but recovered after administration with atropine.

Abbreviations: HR, heart rate; MAP, mean artery pressure; P–D, propofol plus dexmedetomidine; P–H, propofol plus hydromorphone; RR, respiration rate; T0, before admission; T1, 30 minutes; T2, 1 hour; T3, 2 hours; T4, 6 hours; T5, 12 hours after admission; T6, 10 minutes after extubation.

Table 3 Blood gas analysis in different groups

Group	SPO2	PaO2	PaCO2	pH
P–H group	100	191.1±71.1	43.3±6.0	7.35±0.03
P–D group	100	190.0±61.2	42.3±4.3	7.38±0.03

Abbreviations: PaCO₂, partial pressure of CO₂; PaO₂, partial pressure of O₂; P–D, propofol plus dexmedetomidine; P–H, propofol plus hydromorphone; SPO₂, peripheral capillary oxygen saturation.

Figure 1 Comparison of IL-6 by ELISA (A), CSI (B), and Ramsay sedation score (C) between P–H group and P–D group at different time-points.

Notes: *P<0.05 vs T0, ^#P<0.05 vs P–D group.
Abbreviations: CSI, cerebral state index; ELISA, enzyme-linked immunosorbent assay; IL-6, interleukin-6; P–D, propofol plus dexmedetomidine; P–H, propofol plus hydromorphone; PO EXTU, post-extubation.