Growth hormone deficiency and cerebral palsy

Figures & data

Table 1 Presumed causes of cerebral palsy in the children studied

Cause	Number	Incidence (%)
Perinatal hypoxia	22	47.8
Prematurity	14	30.4
Prenatal asphyxia	4	8.7
Prenatal infections	3	6.5
Postnatal encephalitis	3	6.5

Table 2 Disabilities found at admission

Disability	Number	Prevalence (%)
Motor disabilities1	45	97.8
Impairment of speech	36	78.2
Gastrointestinal problems	36	78.2
Mental disadvantage	35	76
Seizures2	22	47.8
Visual affectations	15	32.6
Lack of speech	5	10.8
Blindness	3	6.5

Notes: The prevalence is related with every specific disability observed. Most of the children presented two or more of these disabilities.

1 Motor disabilities reflect either hypotonic or spastic states.

2 Seizures had been treated with one or more antiepilepsy drugs.

Table 3 Biochemical data, Tanner’s stage, height percentile (P) and BMI of the patients studied

Patient number	Age (years)	GH peak (ng.mL^−1)	IGF-1 (ng.mL^−1)	IGFBP3 (μg.mL^−1)	Tanner stage	P	BMI Kg.(m^2)^−1
1	3	NP	24	2.6	1	<3	17
2	3.5	NP	55	3.2	1	15	16.5
3	3.5	NP	96	4.8	2	45	21.5
4	4	NP	26	2.8	1	<3	17
5	4	NP	45	3.4	1	<3	19
6	4	NP	52	3.7	1	10	18.5
7	4.5	NP	52	3.6	1	<3	20
8	4.5	NP	58	3.5	1	<3	20.5
9	4.5	4.2	25	2.3	1	<3	16.5
10	5	NP	62	3.8	1	<3	18
11	5	3.7	31	2.7	1	<3	18
12	5	NP	115	3.9	1	55	21
13	5	NP	89	3.7	1	40	22
14	5	7.5	35	2.5	1	<3	16.5
15	5	5.3	39	2.7	1	<3	16
16	5.5	NP	61	3.9	1	<3	18
17	5.5	NP	34	2.7	1	<3	17
18	5.5	2.8	27	2.7	1	<3	18
19	5.5	4.7	37	2.9	1	<3	16.5
20	5.5	NP	49	3.4	1	<3	17
21	5.5	6.2	32	3.1	1	<3	15.5
22	6	2.1	25	2.5	1	<3	17.5
23	6	5.8	36	2.4	1	<3	17
24	6	NP	41	2.7	1	<3	16.5
25	6	NP	38	3	1	<3	18
26	6	NP	125	4.3	1	10	21
27	6	NP	29	2.6	1	<3	17.5
28	6	2.1	25	2.2	1	<3	16.5
29	6.5	NP	36	3.1	1	<3	18
30	6.5	5.2	32	3	1	<3	18.5
31	6.5	6.8	37	3.2	1	<3	16
32	6.5	NP	137	3.9	1	15	21
33	6.5	NP	34	3.2	1	<3	16.5
34	6.5	NP	123	4.6	1	15	19
35	7	NP	40	3.2	1	<3	17.5
36	7	NP	125	4.5	1	15	21
37	7	NP	163	4.8	1	25	22.5
38	7.5	NP	183	5.1	2	35	21.5
39	7.5	NP	98	4.1	1	15	17.5
40	8	NP	76	3.9	1	10	18
41	8	NP	45	3.4	1	<3	17.5
42	9	NP	41	3.2	1	<3	17
43	9	NP	166	4.3	2	15	20
44	9.5	NP	48	3.2	2	<3	17
45	10	NP	43	2.9	2	<3	17.5
46	11	NP	55	2.7	3	<3	16

Lower limits for age.- IGF-1: 42 ng.mL⁻¹ (3–5 years), 88 ng.mL⁻¹ (6–8 years), 110 ng.mL⁻¹ (9–11 years). IGFBP3: 3.4 μg.mL⁻¹. BMI: 18 Kg.(m²)⁻¹.