Topical calcineurin inhibitors in systemic lupus erythematosus

Figures & data

Table 1 Topical calcineurin inhibitors in cutaneous lupus erythematosus

References	Patients	Treatment	Successful treatment
^Citation48	3 SLE, 4 DLE	tacrolimus 0.1%	3 SLE, 1 DLE
^Citation49	2 DLE	tacrolimus 0.03% in clobetasol propionate 0.05%	2 DLE
^Citation50	1 DLE	pimecrolimus 1%	1 DLE
^Citation51	1 LET	tacrolimus 0.1%	1 LET
^Citation52	1 SLE, 2 SCLE	tacrolimus 0.1%	1 SLE, 2 SCLE
^Citation53	3 SLE	tacrolimus 0.1%	3 SLE
^Citation54	1 SCLE	tacrolimus 0.1%	1 SCLE
^Citation55	1 DLE	tacrolimus 0.1%	1 DLE
^Citation56	5 DLE, 4 SCLE, 2 SLE	tacrolimus 0.1%	3 DLE, 2 SCLE, 2 SLE
^Citation57	4 DLE, 3 SLE, 2 SCLE, 2 LET	pimecrolimus 1%	4 DLE, 3 SLE, 2 SCLE, 2 LET
^Citation58	10 DLE	pimecrolimus 1%	10 DLE
^Citation60	5 DLE	tacrolimus 0.1%	5 DLE
^Citation61	1 SCLE	tacrolimus 0.1%	1 SCLE
^Citation62	1 SCLE	tacrolimus 0.1%	1 SCLE
^Citation63	4 DLE	tacrolimus 0.1%	4 DLE
^Citation64	2 SLE, 2 DLE	tacrolimus 0,1%	1 SLE, 1 DLE
^Citation65	1 SLE/lichen planus	tacrolimus 0.1%	1 SLE/lichen planus
^Citation66	13 SLE, 4 DLE, 1 SCLE	tacrolimus 1% vs clobetasol propionate 0.05%	13 SLE, 4 DLE, 1 SCLE, fewer side effects
^Citation67	18 CLE	tacrolimus 0.3% plus clobetasol vs monotherapy	Better results with combination

Abbreviations: CLE, cutaneous lupus erythematosus; DLE, discoid lupus erythematosus; SCLE, subacute cutaneous lupus erythematosus; SLE, systemic lupus erythematosus; LET, lupus tumidus.

Figure 1 Two patients with SCLE lesions on upper right limb and SCLE lesions on soles, respectively, before (A, C) and after (B, D) treatment with tacrolimus ointment. Copyright © 2004. Reprinted with permission from Lampropoulos CE, Sangle S, Harrison P, Hughes GR, D’Cruz DP. Topical tacrolimus therapy of resistant cutaneous lesions in lupus erythematosus: A possible alternative. Rheumatology (Oxford). 2004;43:1383–1385.

Abbreviation: SCLE, subacute cutaneous lupus erythematosus.

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