BK virus in transplant recipients: current perspectives

Figures & data

Figure 1 Screening and management protocol for BKV infection in kidney transplant recipients.

Abbreviation: PCR, polymerase chain reaction.

Table 1 Adjunctive therapies for BKV infection

Agent	Mechanism
IVIG	Neutralizing antibodies to BK
Leflunomide	Active metabolite inhibits viral replication via pyrimidine depletion
Cidofovir	Selective inhibition of viral DNA synthesis
Fluoroquinolones	Inhibit viral replication and helicase activity of the SV40 large tumor antigen
mTOR inhibitors	Inhibition of p70S6K phosphorylation with reduced BK virus large T antigen expression
BKV-specific T cells	T cell antiviral response

Abbreviations: IVIG, intravenous immunoglobulin; mTOR, mechanistic target of rapamycin.