The effects of timing of prophylaxis, type of anesthesia, and use of mechanical methods on outcome in major orthopedic surgery – subgroup analyses from 17,701 patients in the XAMOS study

Figures & data

Figure 1 Incidences of symptomatic thromboembolic events and treatment-emergent major bleeding events by timing of first dose of prophylactic therapy.

Notes: (A) Rivaroxaban. (B) Standard of care. *95% confidence interval. Results are presented for the safety population (patients who received at least one dose of rivaroxaban or SOC).
Abbreviations: EMA, European Medicines Agency; SOC, standard of care.

Figure 2 Incidences of events by timing of first dose of thromboprophylaxis.

Notes: (A) Symptomatic thromboembolic events. (B) Treatment-emergent bleeding events. Results are presented for the safety population (patients who received at least one dose of rivaroxaban or SOC).
Abbreviations: CI, confidence interval; EMA, European Medicines Agency; OR, odds ratio; SOC, standard of care.

Figure 3 Types of anesthesia used in the XAMOS study.

Abbreviation: SOC, standard of care.

Figure 4 Incidences of events by type of anesthesia.

Notes: (A) Symptomatic thromboembolic events. (B) Bleeding events. Results are presented for the safety population (patients who received at least one dose of rivaroxaban or SOC). ^aTreatment emergent.
Abbreviations: CI, confidence interval; EMA, European Medicines Agency; OR, odds ratio; SOC, standard of care.

Table 1 Incidence of symptomatic thromboembolic events by type of surgery and anesthesia

Type of anesthesia	Hip surgery			Knee surgery
	Rivaroxaban	SOC	Total	Rivaroxaban	SOC	Total
All, % (n/N)	0.6 (28/4,688)	1.2 (55/4,637)	0.9 (83/9,325)	1.2 (50/4,052)	1.6 (62/3,950)	1.4 (112/8,002)
General, % (n/N)	0.9 (19/2,026)	1.2 (24/1,940)	1.1 (43/3,966)	1.7 (20/1,194)	2.5 (29/1,164)	2.1 (49/2,358)
Neuraxial, % (n/N)	0.3 (8/2,550)	1.0 (27/2,596)	0.7 (35/5,146)	0.9 (23/2,622)	1.1 (28/2,557)	1.0 (51/5,179)

Note: Results are presented for the safety population (patients who received at least one dose of rivaroxaban or SOC).

Abbreviation: SOC, standard of care.

Figure 5 Incidences of symptomatic thromboembolic events in patients receiving rivaroxaban or SOC with and without the use of mechanical thromboprophylaxis.

Note: Results are presented for the safety population (patients who received at least one dose of rivaroxaban or SOC).
Abbreviation: SOC, standard of care.