Blood pressure and fasting lipid changes after 24 weeks’ treatment with vildagliptin: a pooled analysis in >2,000 previously drug-naïve patients with type 2 diabetes mellitus

Figures & data

Table 1 Mean changes in blood pressure, fasting lipid parameters, and weight with vildagliptin at week 24

Parameters	Vildagliptin qd/bid n=2,108		Mean change	P-value
	Baseline value	Endpoint value
BP parameters, mean ± SE
Systolic BP, mmHg	132.5±0.32	129.8±0.34	−2.70±0.30	<0.0001
Diastolic BP, mmHg	81.2±0.18	79.6±0.19	−1.64±0.18	<0.0001
Fasting lipid parameters, mean ± SE
Fasting triglycerides (mmol/L)	2.00±0.02	1.80±0.02	−0.20±0.02	<0.0001
VLDL (mmol/L)	0.90±0.01	0.83±0.01	−0.07±0.01	<0.0001
LDL (mmol/L)	3.17±0.02	3.04±0.02	−0.13±0.02	<0.0001
Total cholesterol (mmol/L)	5.26±0.02	5.08±0.02	−0.18±0.02	<0.0001
Non-HDL (mmol/L)	4.07±0.02	3.87±0.02	−0.21±0.02	<0.0001
HDL (mmol/L)	1.19±0.01	1.22±0.01	0.03±0.004	<0.001
Body weight (mean ± SE, kg)	86.16±0.41	85.67±0.40	−0.48±0.08	<0.001

Abbreviations: BP, blood pressure; bid, twice daily; HDL, high density lipoprotein; LDL, low density lipoprotein; qd, once daily; SE, standard error; VLDL, very low density lipoprotein.

Figure 1 Change in systolic (A) and diastolic (B) blood pressure (mmHg), change in triglycerides (C), VLDL (D), and HDL (E) (mmol/L) as a function of change in body weight (kg).

Notes: Solid lines are the best fit regressions from all 2,108 data points and the shaded areas represent the minimum and maximum slopes calculated from the ±95% confidence limits of the slopes. The X-axis limits are set to two standard deviations around the mean change in weight.
Abbreviations: HDL, high density lipoprotein; VLDL, very low density lipoprotein.