Predictive value of NT-proBNP for 30-day mortality in patients with non-ST-elevation acute coronary syndromes: a comparison with the GRACE and TIMI risk scores

Figures & data

Table 1 Baseline characteristics of the included NSTE-ACS patients

Variable	Total, N=1324 (%)
Age (years), mean ± SD	73.1±11.61
Male, gender	861 (65)
Risk factors
Diabetes mellitus	295 (22.3)
Smoking	349 (26.4)
Hypercholesterolaemia	471 (35.6)
Family history	437 (33.0)
Hypertension	762 (57.6)
History of disease
Myocardial infarction	247 (18.7)
Percutaneous coronary intervention	248 (18.7)
Coronary artery bypass graft	186 (14.0)
Chronic renal failure	55 (4.2)

Abbreviations: NSTE-ACS, non-ST-elevation acute coronary syndromes; SD, standard deviation.

Table 2 Coronary intervention data of the studied NSTE-ACS patients (N=1324)

Data on coronary intervention	N (%)
Coronary angiography performed	1134 (85.6)
Time between admission and angiography (hours)
≤24	685 (51.7)
>24–48	152 (11.5)
>48	288 (21.8)
Number of vessel disease
0	104 (7.9)
1	336 (25.4)
2	261 (19.7)
3	329 (24.8)
LM	22 (1.7)
LM +3	47(3.5)
Treatment
Conservative	183 (13.8)
CABG	241 (18.2)
PCI	646 (48.8)

Abbreviations: NSTE-ACS, non-ST-elevation acute coronary syndromes; CABG, coronary artery bypass grafting; LM, left main; PCI, percutaneous coronary intervention.

Table 3 Logistic regression analysis of NT-proBNP, the GRACE risk score and the TIMI NSTE-ACS risk score for 30-day mortality prediction

	Variables in the equation
	B	SE	Wald	df	P-value	OR	95% CI for OR
							Lower	Upper
Step 1a
NT-proBNP	0.640	0.215	8.874	1	0.003	1.897	1.245	2.891
GRACE	0.021	0.008	7.952	1	0.005	1.021	1.006	1.037
TIMI	−0.201	0.199	1.023	1	0.312	0.818	0.553	1.208
Constant	−11.209	1.686	44.183	1	0.000	0.000

Note:

a Variable(s) entered on step 1: NT-proBNP, GRACE risk score, TIMI risk score.

Abbreviations: BNP, brain natriuretic peptide; CI, confidence interval; df, degree of freedom; GRACE, Global Registry of Acute Coronary Events; NSTE-ACS, non-ST-elevation acute coronary syndromes; NT, N-terminal fragment; OR, odds ratio; SE, standard error; TIMI, thrombolysis in myocardial infarction.

Figure 1 ROC curves for comparisons of NT-proBNP and the GRACE and TIMI-NSTE-ACS risk scores (N=692, mortality cases N=29).

Abbreviations: BNP, brain natriuretic peptide; GRACE, Global Registry of Acute Coronary Events; NT, N-terminal fragment; NSTE-ACS, non-ST-elevation acute coronary syndromes; ROC, receiver operating characteristic.