Thromboangiitis obliterans episode: autoimmune flare-up or reinfection?

Figures & data

Table 1 Overview of the summarized data on sTLR4, sTLR2, hsCRP, and neopterin for TAO patients in the acute and quiescent phase of the disease and the control group

	TAO acute phase	TAO quiescent phase	Controls
Number of subjects	28	23	31
Number of patients with history of major amputation	4	3
sTLR4 (mean ± SE), ng/mL	3.3±0.59	1.98±0.18	4.55±0.87
	P=0.012*
sTLR2 (mean ± SE), ng/mL	7.6±1.89	4.22±0.94	7.2±1.98
	P=0.26
Neopterin (mean ± SE), nmol/L	13.1±0.8	8.2±0.6	8.9±0.3
	P=0.003*
hsCRP (mean ± SE), µg/mL	14.08±3.2	5.76±3.62

Notes:

* P-value<0.05.

Abbreviations: sTLR, serum level of toll-like receptor; hsCRP, high-sensitivity C-reactive protein; TAO, thromboangiitis obliterans; SE, standard error of mean.

Table 2 Mean sTLR4 and sTLR2 in patients with positive and negative hsCRP according to two cutoff values

	TAO hsCRP >3 µm/mL	TAO hsCRP ≤3 µm/mL	TAO hsCRP >7 µm/mL	TAO hsCRP ≤7 µm/mL
sTLR4 (mean ± SE), ng/mL	2.05±0.3	2.97±1.1	2.79±0.6	1.68±0.18
	P=0.95		P=0.031*
sTLR2 (mean ± SE), ng/mL	3.8±0.68	8±4.7	6.6±2.6	2.8±0.3
	P=0.57		P=0.08

Note:

* P-value<0.05.

Abbreviations: sTLR, serum level of toll-like receptor; hsCRP, high-sensitivity C-reactive protein; TAO, thromboangiitis obliterans; SE, standard error of mean.