Expression of Hypoxia-Inducible Factor-1α (HIF1A) and Lp-PLA2 in Low, Intermediate, and High Cardiovascular Disease Risk Population

Figures & data

Table 1 Baseline Characteristics of Respondents

Risk Factors		Risk Group (%)
		Low	Intermediate	High
Gender	Male	34	92	92
	Female	66	8	8
Age (years)	30–49	15	16	16
	50–69	77	62	54
	70–89	8	22	30
Smoking history	Smoker	29	39	54
	Ex-smoker	17	17	13
	Non-smoker	54	44	33
Exercise	Yes	74	73	38
	No	26	27	62
Body mass index (BMI. kg/m^2)	Underweight (<18.5)	3	13	7
	Normal (18.5–22.9)	26	24	46
	Overweight at risk (23.0–24.9)	17	16	19
	Obese I (25.0–29.9)	30	34	19
	Obese II (≥30.0)	24	13	7
Systolic blood pressure (mmHg)	<120	36	25	12
	120–129	9	11	4
	130–139	10	8	16
	140–179	38	50	56
	≥180	7	6	12
Total cholesterol (mg/dL)	<200	64	73	44
	200–239	17	11	36
	≥240	19	16	20
Total of high-density lipoprotein (HDL) (mg/dL)	≥40	67	54	24
	<40	33	46	76
Total	% (n)	100 (96)	100 (38)	100 (26)

Table 2 Levels of HIF1A Dan Lp-PLA2 Based on FRS

Risk Group	Lp-PLA2 (Mean ± SD)	HIF-1a (Mean ± SD)	Pearson’s Correlation
			Correlation Coefficient (r)	Sig. (2-Tailed)
Low	0.1008 ± 0.0100^a	0.279 ±0.0488^a	0.529**	0
Intermediate	0.1005 ± 0.0095^ab	0.277 ± 0.0348^a	0.512**	0
High	0.095 ± 0.0093^b	0.287 ± 0.0332^a	0.715**	0

Notes: The notation shows the mean difference between groups. r_{(5%; 94)} = 0.203; r_{table (5%; 38)} = 0.321; r_{table (5%; 26)} = 0.383. **Correlation is significant at the 0.05.

Abbreviations: CVD, cardiovascular disease; FRS, Framingham Risk Score; HIF1A, hypoxia-inducible factor-1α; HDL, high-density lipoprotein; LDL, low-density lipoprotein; LP-PLA2, lipoprotein-associated phospholipase; LysoPC, lysophopshatidylclcholine; MCP-1, monocyte chemoattractant protein-1; oxLDL, oxidized LDL; OxNEFA, nonesterified fatty acid.