Review and recommendations on management of refractory raised intracranial pressure in aneurysmal subarachnoid hemorrhage

Figures & data

Table 1 Summary of clinical trials of hypertonic saline in aneurysmal subarachnoid hemorrhage

Study	Study type	Number of treatments	Dose	ICP reduction	Other outcome
Suarez et al^Citation35	Retrospective	29	Continuous 3% NaCl acetate	Not studied	No effect on CBF velocities
Tseng et al^Citation32	Retrospective	17	23.4% NaCl boluses	74.7% at 60 minutes	Improvement of perfusion defects on xenon CT scans
Bentsen et al^Citation36	Prospective randomized, single-blind, placebo-controlled	22	7.2% NaCl in 6% hydroxyethyl starch boluses	37% compared with control at 64 minutes	Beneficial hemodynamic effects with increased cardiac index
Tseng et al^Citation33	Prospective	35	23.5% NaCl boluses	93.1% at 60 minutes	Improvement in CBF on xenon CT scans, and associated with improved outcome at discharge
Al-Rawi et al^Citation37	Prospective	44	23.5% NaCl boluses	67.4% at 30 minutes	Improvement in cerebral oxygenation on xenon CT scans and favorable outcome at 12 months

Abbreviations: ICP, intracranial pressure; CBF, cerebral blood flow; CT, computed tomography; NaCl, sodium chloride.

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