The Diastolic Oscillation Amplitude Used as an Arterial Aging Indicator

Figures & data

Figure 1 Radial pulse wave recording in a healthy adult. It was normalized in amplitude (0% −100%). The oscillation observed at the beginning of diastole depends on the distal arteries compliance.

Abbreviations: DA, diastolic amplitude; RAIx, radial augmentation index.

Figure 2 Effects of aging in healthy individuals. With increasing age, the systolic wave widens, and the oscillation amplitude flattens.

Table 1 General Characteristics of All Cases

	Males	Women	p
N [Cases]	242	251
Age [Years]	38 [26–49]	39 [25–51]	0.91
Height [m]	1.75 [1.70–1.80]	1.61 [1.58–1.66]	<0.0001
BMI [Kg/m^2]	25.90 [23.70–28.60]	23.40 [21.32–26.97]	<0.0001
SBP [mmHg]	125.00 [116.00–135.00]	115.00 [105.00–120.75]	<0.0001
DBP [mmHg]	80.00 [75.00–88.00]	74.00 [67.25–80.00]	<0.0001
MAP [mmHg]	96.67 [90.00–103.33]	86.67 [80.00–93.33]	<0.0001
HR [ppm]	71.81 ± 10.42	76.38 ± 11.23	<0.0001
RAIx [%]	58.50 [44.00–70.80]	68.50 [51.70–79.85]	<0.0001
DA [%]	14.91 [11.50–18.22]	11.60 [8.70–15.40]	<0.0001
PWV [m/s]	6.71 [5.77–7.75]	6.83 [5.83–8.33]	0.057

Notes: Results are expressed as mean ± standard deviation (SD) or median and 1st–3rd quartiles, as appropriated.

Abbreviations: BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; HR, heart rate; RAIx, radial augmentation index; DA, amplitude of diastolic oscillation; PWV, aortic blood pressure wave velocity.

Figure 3 Variation of DA with age in healthy individuals of both sexes. Males: Gray diamonds, Females: Black squares. The approximation curves are 2nd order polynomials. The determinant coefficient values are R²= 0.35 for females and R²= 0.49 for males.

Table 2 Linear Regression Coefficients of the Variable DA, for Both Sexes

F statistic: 120; p value ≪ 10^−3		Adjusted R^2: 0.55
Variable	Β Coefficient	Statistical t	p value
RAIx	−0.15	−10.3	<0.0001
Age	−0.11	−5.24	<0.0001
Height	5.06	2.04	0.04
Male sex	−1.69	−1.68	0.09
Male sex*Age	0.07	3.17	0.001
Interception	18.31	4.36	<0.0001

Abbreviations: DA, amplitude of diastolic oscillation; RAIx, radial augmentation index.

Figure 4 Variation of DA with C2.

Notes: Data from Wang et al.¹⁶

Wang L, Xu L, Zhou S, et al. Design and implementation of a pulse wave generator based on Windkessel model using field programmable gate array technology. Biomed Signal Process Control. 2017;36:93–101. doi:10.1016/j.bspc.2017.03.008

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