The “Pulse Time Index of Norm” highly correlates with the left ventricular mass index in patients with arterial hypertension

Figures & data

Table 1 The baseline characteristics of the examined patients, n=137

Characteristic	Value
Male, n (%)	83 (61)
Age, mean (SD) years	46 (18)
Height, mean (SD) cm	168 (7)
Weight, mean (SD) kg	83 (17)
SBP, mean (SD) mmHg	144 (23)
DBP, mean (SD) mmHg	82 (13)
Heart rate, mean (SD) bpm	73 (14)
Hypertension, n (%)	137 (100)
Duration of hypertension history, mean (SD) years	6 (3)
Medication: thiazide diuretics, n (%)	80 (58)
Medication: angiotensin-receptor blockers, n (%)	91 (66)
Medication: beta-blockers, n (%)	60 (44)
Medication: other, n (%)	51 (37)
Drug combinations, n (%)	128 (93)
Previous MI or stroke, n (%)	26 (19)
LVH, n (%)	75 (55)
Renal disease, n (%)	4 (3)

Abbreviations: DBP, diastolic blood pressure; LVH, left ventricular hypertrophy; MI, myocardial infarction; SBP, systolic blood pressure; SD, standard deviation.

Figure 1 The PTIN calculation principle.

Notes: T1, T2 and Tn are the periods in which the PWV does not exceed the cutoff value of 10 m/second. PTIN, % = (T1 + T2 +… + Tn)/Tm ×100, where Tm is the entire period of monitoring, Pulse Time index of norm.^2,22
Abbreviations: PTIN, Pulse Time Index of Norm; PWV, pulse wave velocity.

Figure 2 Histogram of PTIN distribution – observed frequencies and expected normal curve.

Note: Pulse Time index of norm.^2,22
Abbreviation: PTIN, Pulse Time Index of Norm.

Figure 3 Correlation between the LVMI (g/m²) and: (A) the PTIN (%), (B) the SBP load (%), and (C) the DBP load (%).

Notes: Pulse Time Index of norm.^2,22
Abbreviations: DBP, diastolic blood pressure; SBP, systolic blood pressure; LVMI, left ventricular mass index; PTIN, Pulse Time Index of Norm.

Table 2 The correlations between the echocardiographic data and the BPLab Vasotens® (Petr Telegin company, Nizhny Novgorod, Russian Federation) indices

	LVM/height^2.7		LVM/BSA
	r	P-value	r	P-value
PTIN	−0.72	0.0001	−0.67	0.0001
Mean 24-hour PWV	0.32	0.01	0.32	0.01
Variability of PWV	0.12	>0.05	0.12	>0.05
SBP load	0.41	0.001	0.37	0.01
DBP load	0.47	0.001	0.37	0.01
Mean SBP	0.14	>0.05	0.15	>0.05
Mean DBP	0.29	>0.05	0.19	>0.05

Note: Pulse Time Index of Norm.^2,22

Abbreviations: BSA, body surface area; DBP, diastolic blood pressure; LVM, left ventricular mass; PTIN, Pulse Time Index of Norm; PWV, pulse wave velocity; SBP, systolic blood pressure.

Figure 4 Medians, limits of the fifth and 95th percentiles and non-outlier range of PTIN according to 24-hour awake and asleep periods in patients with and without LVH.

Notes: Pulse Time Index of norm.^2,22
Abbreviations: LVH, left ventricular hypertrophy; PTIN, Pulse Time Index of Norm; h, hour.

PosokhovINPulse wave velocity 24-hour monitoring with one-site measurements by oscillometryMed Devices (Auckl)20136111523549868

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PosokhovINKonradiAOShlyakhtoEVMamontovOVOrlovAVRogozaANDay-to-day repeatability of the ‘Pulse Time Index of Norm’Med Devices (Auckl)20147293324600253

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