Utility of high-sensitivity cardiac troponin T in patients receiving anthracycline chemotherapy

Figures & data

Table 1 Baseline and follow-up cardiac biomarkers of all patients

	Baseline	At follow-up	Change
	Median (25th, 75th percentiles)
cTnI (ng/mL)	0.00 (0.00, 0.01)	0.05 (0.01, 0.09)	0.04 (0.00, 0.08)
cTnT (ng/mL)	0.00 (0.00, 0.00)	0.00 (0.00, 0.00)	0.00 (0.00, 0.00)
CKMB (ng/mL)	0.80 (0.50, 0.80)	1.00 (0.70, 1.50)	0.40 (0.00, 0.90)
NT-proBNP(pg/mL)	46.10 (34.10, 106.10)	88.30 (67.80, 135.90)	20.50 (−11.50, 88.00)
hscTnT (pg/mL)	1.39 (0.00, 3.36)	19.10 (5.90, 28.70)	16.90 (4.10, 25.60)
Pre-MUGA EF (%)	58.00 (56.00, 58.00)	58.00 (53.00, 65.00)	−3.00 (−6.00, 4.00)

Abbreviations: cTnI, cardiac troponin I; cTnT, cardiac troponin T; CKMB, creatine kinase MB; NT-proBNP, N-terminal pro-B-type natriuretic peptide; hscTnT, high-sensitivity cTnT; MUGA, multigated acquisition (equilibrium radionuclide ventriculography); EF, ejection fraction.

Table 2 Baseline characteristics stratified by change in EF

Variable	No change in EF decline in EF		P-value
Baseline	Median	Median
cTnI (ng/mL)	0	0	0.48
cTnT (ng/mL)	0	0	1.00
CKMB (ng/mL)	0.7	0.8	0.25
NT-proBNP (pg/mL)	71.4	45.5	0.61
hscTnT (pg/mL)	0.1	2.7	0.07

Abbreviations: cTnI, cardiac troponin I; cTnT, cardiac troponin T; CKMB, creatine kinase MB; NT-proBNP, N-terminal pro-B-type natriuretic peptide; hscTnT, high-sensitivity cTnT; EF, ejection fraction.