Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats

Figures & data

Table 1 Comparison of Fasting Plasma Metabolites and Hormone Concentrations and Enzyme Activities in Healthy Cats Supplemented with and Without Rv-PEM01-99 for 4 Weeks

	Without Rv-PEM01-99 (n=5)		With Rv-PEM01-99 (n=8)
	0 Week	4 Week	0 Week	4 Week
Body weight (kg)	3.3±0.2	3.3±0.2	3.4±0.2	3.4±0.2
BCS	5/9	5/9	5/9	5/9
Glucose (mg/100 mL)	76.0±3.0	78.4±4.0	84.0±3.0	78.3±1.3
TG (mg/100 mL)	38.5±2.0	40.0±2.5	39.0±2.5	46.6±15.7
TC (mg/100 mL)	75.0±6.0	88.0±7.0	77.8±6.2	95.9±6.6
NEFA (mEq/L) 0.44±0.02	0.44±0.02	0.69±0.06	0.73±0.09	0.39±0.06*
TP (g/100 mL)	5.9±0.1	6.1±0.2	6.4±0.1	6.3±0.1
MDA (μmol/L)	1.49±0.15	1.55±0.16	1.89±0.15	1.40±0.16*
Adiponectin (μg/mL)	4.2±0.2	4.6±0.4	5.6±1.0	5.8±0.6
LDH (U/L)	182±20	183±24	218±9	130±9*
AST (U/L)	26.5±1.3	30.0±2.0	27.5±1.3	21.9±1.6
ALT (U/L)	63.5±3.8	57.0±3.2	66.4±3.7	56.5±4.8*
SAA (ng/mL)	15.9±5.2	12.5±2.4	19.2±4.2	4.8±2.7*

Notes: Values are presented as mean ± SE. BCS is the average value of the group. *Significantly different (p<0.05) from 0 week value in the same group.

Abbreviations: BCS, body condition score; TG, triglyceride; NEFA, non-esterified fatty acid; TP, total protein; MDA, malondialdehyde; LDH, lactate dehydrogenase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; SAA, serum amyloid A.

Table 2 Changes in Fasting Plasma Metabolites and Hormone Concentrations and Enzyme Activities in Four Obesity Disease Cats Supplemented with Rv-PEM01-99 for 4 Weeks

	0 Week	4 Week	P value
Body weight (kg)	6.7±1.0	6.6±1.0	0.182
BCS	8.0±0.6/9	8.0±0.6/9	–
Glucose (mg/100 mL)	88.8±1.3	91.3±11.3	0.839
TG (mg/100 mL)	121.5±6.7	85.0±10.9	0.068
TC (mg/100 mL)	200.3±10.7	167.3±18.4*	0.025
NEFA (mEq/L)	0.84±0.09	0.66±0.02	0.143
TP (g/100 mL)	7.0±0.2	6.9±0.2	0.637
MDA (µmol/L)	2.3±0.0	2.2±0.3	0.628
Adiponectin (µg/mL)	1.3±0.1	1.2±0.1	0.391
LDH (U/L)	204.0±53.0	153.3±34.9	0.118
AST (U/L)	47.0±4.7	34.0±4.9*	0.006
ALT (U/L)	61.5±10.7	49.0±11.3	0.110
SAA (ng/mL)	194.3±76.0	27.6±4.7*	0.004

Notes: Data are expressed as mean ± SE. P value was calculated by paired t-test. *Significantly different (p<0.05) from 0 week value.

Abbreviations: BCS, body condition score; TG, triglyceride; NEFA, non-esterified fatty acid; TP, total protein; MDA, malondialdehyde; LDH, lactate dehydrogenase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; SAA, serum amyloid A.