Challenges in the development of future treatments for breast cancer stem cells

Shyam A Patel1 Graduate School of Biomedical Sciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA;2 Department of Medicine – Division of Hematology/Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA

Anicia Ndabahaliye2 Department of Medicine – Division of Hematology/Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA

Philip K Lim2 Department of Medicine – Division of Hematology/Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA

Russell Milton2 Department of Medicine – Division of Hematology/Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA

Pranela Rameshwar2 Department of Medicine – Division of Hematology/Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USACorrespondence[email protected]

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Figure 1 Origins and properties of breast cancer stem cells (CSCs). Origins of CSCs are unclear but may involve accumulation of genetic damage and dysregulation of normal self-renewal. Defining properties include resistance to chemotherapy, mammosphere formation, and in vivo tumor generation in immunodeficient mice.^Citation9

Table 1 Postulated phenotypic changes undergone by breast cancer cells during EMT^{Citation52,Citation53}

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Challenges in the development of future treatments for breast cancer stem cells

Table 1 Postulated phenotypic changes undergone by breast cancer cells during EMT^{Citation52,Citation53}

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Challenges in the development of future treatments for breast cancer stem cells

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Table 1 Postulated phenotypic changes undergone by breast cancer cells during EMTCitation52,Citation53

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Table 1 Postulated phenotypic changes undergone by breast cancer cells during EMT^{Citation52,Citation53}