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Review

90Yttrium ibritumomab tiuxetan in the treatment of non-Hodgkin’s lymphoma: current status and future prospects

Pages 215-227 | Published online: 07 Dec 2022

Figures & data

Figure 1 Autoradiographic localization of 90Y-ibritumomab tiuxetan from lymph node on a patient sampled 4 days after treatment.

Figure 1 Autoradiographic localization of 90Y-ibritumomab tiuxetan from lymph node on a patient sampled 4 days after treatment.

Table 1 Effect of prior treatment on response to radioimmunotherapy (RIT) in follicular lymphoma (FL)

Table 2 First-line therapy in follicular lymphoma (FL) with sequential chemotherapy followed by radioimmunotherapy (RIT)

Figure 2 Panel 1 shows large left lung mass on CT scan with corresponding FDG-avidity, biopsy proven follicular lymphoma. Panel 2, 3 months later shows resolution of mass on CT scan and FDG-negative scan. Panel 3, 12 months after 90Y-ibritumomab tiuextan shows infiltrative mass on CT scan and FDG-avid area apart from the heart. Bronchoscopy was negative for recurrent lymphoma and cultures were negative. Panel 4, 24 months after treatment there is residual scarring with decreased FDG-avidity.

Figure 2 Panel 1 shows large left lung mass on CT scan with corresponding FDG-avidity, biopsy proven follicular lymphoma. Panel 2, 3 months later shows resolution of mass on CT scan and FDG-negative scan. Panel 3, 12 months after 90Y-ibritumomab tiuextan shows infiltrative mass on CT scan and FDG-avid area apart from the heart. Bronchoscopy was negative for recurrent lymphoma and cultures were negative. Panel 4, 24 months after treatment there is residual scarring with decreased FDG-avidity.

Figure 3 CT scan with moderate pleural effusion and small pericardial effusion in patient with serum-sickness like syndrome. Both effusions rapidly cleared with steroid administration.

Figure 3 CT scan with moderate pleural effusion and small pericardial effusion in patient with serum-sickness like syndrome. Both effusions rapidly cleared with steroid administration.

Figure 4 Graphs of sed rate and c-reative protein in patient with serum-sickness like syndrome following immunotherapy with ibritumomab aand rituximab. The rise in inflammatory markers corresponded with attempts at tapering of the dose of steroid.

Figure 4 Graphs of sed rate and c-reative protein in patient with serum-sickness like syndrome following immunotherapy with ibritumomab aand rituximab. The rise in inflammatory markers corresponded with attempts at tapering of the dose of steroid.

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