Stem cell therapeutics: potential in the treatment of inflammatory bowel disease

Figures & data

Table 1 Case reports of IBD outcomes after myeloablation and autologous stem cell transplantation for coincidental malignancy

Disease (n)	Indication	Conditioning	Graft	IBD outcome	Ref
CD (n = 1)	NHL	Chemo	BMSC 3 × 10e8/kg	Remission at 6 mos	^Citation14
				Off immunosuppression
UC (n = 1)	Breast cancer	Chemo	mPBSC ?dose	Remission > 2 yrs	^Citation67
CD (n = 1)	Breast cancer	Chemo	mPBSC ?dose	Remission > 2 yrs	^Citation67
CD (n = 1)	T cell NHL	Chemo	mPBSC 9.8 × 10e8/kg	Remission 7 yrs	^Citation68
				Off immunosuppression
CD (n = 1)	Hodgkin’s	Chemo	mPBSC ?dose	Remission > 3 yrs	^Citation69
				Off immunosuppression
CD (n = 1)	AML	Chemo TBI	BMSC, mPBSC ?dose	Remission > 6 yrs	^Citation70
				Off immunosuppression

Abbreviations: See list in text.

Table 2 Case reports and small series of inflammatory bowel disease outcomes after myeloablation and autologous stem cell transplantation for Crohn’s disease

Disease (n)	Conditioning	Graft	IBD outcome	Ref
CD (n = 1)	Cyc	T-cell depleted	Remission for 9 mos	^Citation71
		CD34+ mPBSC	Recurrent aphthous ulcers
		6.4 × 10e6/kg	Maint. corticosteroids and MTX
CD (n = 1)	Cyc ATG	T cell-depleted	Symptomatic remission for 5 mos	^Citation72
		CD34+ mPBSC	Endoscopic and pathologic improvement, off immunosuppression
		3.4 × 10e6/kg
CD (n = 12)	Cyc ATG	T-cell depleted	Remission in 11 of 12	^Citation15
		CD34+ mPBSC	7–37 mos follow-up
		2 × 10e6/kg	Corticosteroids tapered over 2–6 mos
[*2 of these subjects were already reported by Burt et al in 2003]
CD (n = 1)	Not stated	Not stated	Remission for 8 yrs followed by relapse	^Citation17
CD (n = 1)	Not stated	Not stated	Remission for 6 yrs	^Citation73
CD (n = 4)	Cyc ATG	mPBSC ?dose	Remission in 3 of 4 11–20 mos follow-up	^Citation16
			Off immunosuppression

Abbreviations: See list in text.

Table 3 Case reports and small series of inflammatory bowel disease outcomes after myeloablation and allogeneic stem cell transplantation

Disease (n)	Indication	Conditioning	Graft	IBD outcome	Ref
UC (n = 1)	AML	Not stated	Not stated	Remission 4 yrs	^Citation20
CD (n = 1)	AML	Chemo	AlloBMT CSA for 7 mos	Remission 7 years off immunosuppression	^Citation22
			Steroids for 2 mos
CD (n = 5)	CML	Chemo TBI	AlloBMT, varied	Remission in 4 of 5 patients followed for 4–15 yrs	^Citation23
(A sixth CD patient with AML died 97 days after alloBMT; recurrent CD could not be evaluated)
CD (n = 7) UC (n = 4)	AML, CML, MF	Varied	AlloBMT, varied	Remission in 9 of 10 survivors	^Citation24
CD (n = 1)	IBD, IL-10RB mutation	Chemo	Sibling AlloBMT	Remission 1 yr	^Citation4

Abbreviations: See list in text.

Table 4 Minimal criteria for defining multipotent mesenchymal stem cells²⁷

Adherent to plastic under standard culture conditions Express CD105, CD73 and CD90 Lack expression of CD45, CD34, CD14 or CD11b, CD79a or CD19 and HLA-DR Differentiate to osteoblasts, adipocytes and chondroblasts in vitro

Abbreviations: See list in text.

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