Imatinib as the first and only treatment in Europe for adult patients at significant risk of relapse following gastrointestinal stromal tumor removal

Figures & data

Table 1 Commonly used rating systems for assessing risk of GIST

	Features
NIH: Fletcher^Citation15
Very low	<2 cm and <5 mitotic index
Low	2–5 cm and <5 mitotic index
Intermediate	5–10 cm and <5 mitotic index
	5 cm and 6–10 mitotic index
High	>5 cm and >5 mitotic index
	>10 cm and any mitotic index or any size and >10 mitotic index
NIH: Miettinen^Citation44
Probably benign	Gastric: ≤5 cm and ≤5 mitotic index
	Intestinal: ≤2 cm and ≤5 mitotic index
Uncertain or low	Gastric: >5 cm, ≤10 cm, and ≤5 mitotic index
Malignant potential	Intestinal: >2 cm, ≤5 cm, and ≤5 mitotic index
Probably malignant	Gastric: >10 cm or >5 mitotic index
	Intestinal: >5 cm or 5 mitotic index
AFIP: Miettinen^Citation40
Very low, if any malignant potential	≤2 cm, and ≤5 mitotic index
Low malignant potential	Gastric: >2 cm and ≤10 cm, and ≤5 mitotic index; ≤2 cm, and >5 mitotic index
	Intestinal: >2 cm and ≤5 cm, and ≤5 mitotic index
Intermediate	Gastric: >10 cm and ≤5 mitotic index
Malignant potential	>2 cm and ≤5 cm, and >5 mitotic index
	Intestinal: >5 cm and <10 cm, and ≤5 mitotic index
High malignant potential	Gastric: >5 cm and >5 mitotic index
	Intestinal: >10 cm or >5 mitotic index

Notes: mitotic index = number of mitoses per 50 high-power field.

Abbreviations: AFIP, Armed Forces Institute of Pathology; NIH, National Institutes of Health.

FletcherCDBermanJJCorlessCDiagnosis of gastrointestinal stromal tumors: a consensus approachHum Pathol20023345946512094370

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MiettinenMEl-RifaiWHL SobinLLasotaJEvaluation of malignancy and prognosis of gastrointestinal stromal tumors: a reviewHum Pathol20023347848312094372

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MiettinenMLasotaJGastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosisArch Pathol Lab Med20061301466147817090188

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