Combination therapy with dutasteride and tamsulosin for the treatment of symptomatic enlarged prostate

Figures & data

Table 1 Pharmacokinetics of dutasteride

Bioavailability	60%
Steady state	3 months
Peak serum concentration	2–3 hours
Volume of distribution	511 L
Elimination half-life	5 weeks

Figure 1 Dutasteride chemical structure.

Table 2 Sexual adverse events from dutasteride efficacy and safety study

Adverse event	Placebo	Dutasteride
Impotence	4.00%	7.30%
Decreased libido	2.10%	4.20%
Gynecomastia	0.70%	2.30%
Ejaculation disorder	0.80%	2.20%

Table 3 Pharmacokinetics of tamsulosin

Bioavailability	90%
Steady state	5 days
Peak serum concentration	4–6 hours
Volume of distribution	16 L
Elimination half-life	15 hours

Figure 2 Tamulosin chemical structure.