Effect of an isoflavones-containing red clover preparation and alkaline supplementation on bone metabolism in ovariectomized rats

Figures & data

Figure 1 Effect of ovariectomy and supplementation of RCE and RCE + BP on estradiol A) uterine weight B) and osteocalcin level C) (mean ± SD).

Notes: *p < 0.01 vs sham-operated (group A); **p < 0.05 vs untreated ovariectomy rats (group B), ^#p < 0.05 vs group C (RCE-treated OVX rats).

Abbreviations: BP, calcium bicarbonate, sodium bicarbonate, magnesium and potassium carbonate, and bisodium phosphate; OVX, ovariectomized; RCE, red clover extract.

Figure 2 Effect of ovariectomy and supplementation of RCE and RCE + BP on bone mineral density A) bone mineral content/body wt ratio B) and cancellous bone mass C) (mean ± SD).

Notes: *p < 0.01 vs sham-operated (group A); **p < 0.05 vs untreated ovariectomy rats (group B); ^#p < 0.05 vs group C (RCE-treated OVX rats).

Abbreviations: BP, calcium bicarbonate, sodium bicarbonate, magnesium and potassium carbonate, and bisodium phosphate; OVX, ovariectomized; RCE, red clover extract.

Figure 3 Effect of ovariectomy and supplementation of RCE and RCE + BP on maximal load on femoral neck (mean ± SD).

Notes: *p < 0.01 vs sham-operated (group A); **p < 0.05 vs untreated ovariectomy rats (group B).
Abbreviations: BP, calcium bicarbonate, sodium bicarbonate, magnesium and potassium carbonate, and bisodium phosphate; OVX, ovariectomized; RCE, red clover extract.

Figure 4 Effect of ovariectomy and supplementation of RCE and RCE + BP on urinary DPD excretion and bone-specific ALP.

Notes: *p < 0.01 vs sham-operated (group A); **p < 0.05 vs untreated ovariectomy rats (group B); ^#p < 0.05 vs group C (RCE-treated OVX rats).
Abbreviations: ALP, alkaline phosphatase; BP, calcium bicarbonate, sodium bicarbonate, magnesium and potassium carbonate, and bisodium phosphate; OVX, ovariectomized; RCE, red clover extract.