Reducing hip fracture risk with risedronate in elderly women with established osteoporosis

Figures & data

Table 1 Criteria for enrollment in the HIP study³

Age 70–79 years	Age ≥ 80 years
Femoral neck T-scorea ≤ −4	Femoral neck T-scorea ≤ −4
or	or
Femoral neck T-scorea ≤ −3 plus ≥1 clinical risk factor for hip fractureb	Femoral-neck T-scorea ≤ −3 plus hip-axis length ≥11.1 cm
	or
	≥1 non-skeletal risk factor for hip fractureb

a Bone mineral density at the femoral neck more than 4 or 3, as applicable, standard deviations below the mean peak value in young adults. For purposes of enrollment, femoral neck T-scores were calculated according to the manufacturer’s reference data base for the densitometer. The femoral-neck T-scores at baseline were later recalculated according to reference data from nhAnes III.¹⁰

b Difficultystanding from a sitting position; poor tandem gait; fall-related injury during the previous year; psychomotor score of ≤5 on the Clifton ModifiedGibson Spiral Maze Test;¹¹ current smoking or smoking during the previous 5 years; maternal history of hip fracture; previous hip fracture; and/or hip-axis length of ≥11.1 cm.

Table 2 Demographic and baseline characteristics

	Women with established osteoporosisa
	Placebo n = 566	Risedronate n = 1090
Age, years
Mean ±s D	77 ± 5	77 ± 5
≥80 years, n (%)	122 (22)	250 (23)
Time since menopause, years, mean ± SD	31 ± 9	31 ± 9
Height, cm, mean ± SD	155.1 ± 7.2	154.6 ± 7.0
Weight, kg, mean ± SD	58.8 ± 10.6	58.1 ± 10.4

a Femoral neck T-score NHANES III ≤ −2.5 and ≥ 1 prevalent vertebral fractures.

Abbreviation: SD, standard deviation.

Figure 1 Study population.

Abbreviations: BMD, bone mineral density; ITT, intention to treat.

Table 3 Cumulative hip fracture incidence (Kaplan-Meier) 0–3 years and hip fracture efficacy of risedronate

	ITT population from the HIP study^Citation3		Women with established osteoporosisa
	Placebo n = 3134	Risedronate n = 6197	Placebo n = 566	Risedronate n = 1090
Hip fracture incidence, %	3.9	2.8	7.4	3.8
Hip fracture efficacy
RR (95% CI)	–	0.7 (0.6–0.9)	–	0.54 (0.32–0.91)
P-value		0.02		0.019

a Femoral neck T-score NHANES III ≤ −2.5 and ≥ 1 prevalent vertebral fractures.

Abbreviations: ITT, intention to treat; CI, confidence interval; RR, relative risk.

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