Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma

Figures & data

Table 1 Homocysteine, vitamin B6, vitamin B12, and folate levels in the study groups

Group	Number of subjects	Hcy (μmol/L)	Vitamin-B12 (pg/mL)	Vitamin-B6 (μg/L)	Folate (ng/mL)
Control	40	8.68 ± 2.59	345.55 ± 201.75	20.09 ± 5.54	9.00 ± 6.39
NTG	48	11.27 ± 4.91	344.46 ± 247.84	30.50 ± 11.29a	9.71 ± 3.86
PXG	38	15.46 ± 9.27a	277.16 ± 139.08	22.81 ± 11.71	10.82 ± 4.92
POAG	34	11.28 ± 4.80	368.24 ± 262.65	30.22 ± 12.15a	11.59 ± 9.40

Note: ^aIndicates statistically significant (P < 0.05).

Abbreviations: NTG, normal tension glaucoma; PXG, pseudoexfoliative glaucoma; POAG, primary open-angle glaucoma; Hcy, homocysteine.

Table 2 Gender and age data for study groups

Group	Mean age and range	Gender
Control	62 ± 8.1 years (range: 50–71)	18 males (45%) and 22 females (55%)
NTG	56 ± 6.8 years (range: 45–69)	24 males (50%) and 24 females (50%)
PXG	63 ± 6.3 years (range: 55–76)	20 males (52.63%) and 18 females (47.37%)
POAG	58 ± 7.5 years (range: 45–75)	14 males (41.18%) and 20 females (58.82%)

Abbreviations: NTG, normal tension glaucoma; PXG, pseudoexfoliative glaucoma; POAG, primary open-angle glaucoma.

Figure 1 Scatterplot demonstrating distribution of plasma homocysteine levels in the study groups.

Figure 2 Scatterplot demonstrating distribution of serum vitamin B12 levels in the study groups.

Figure 3 Scatterplot demonstrating distribution of serum folate levels in the study groups.

Figure 4 Scatterplot demonstrating distribution of plasma vitamin B6 levels in the study groups.

Figure 5 A) Homocysteine catabolism to pyruvate and vitamin B6 (pyridoxine)-transaminase. B) Pathway for the synthesis of serotonin from tryptophan and pyridoxine as a coenzyme.