Activity and potential role of licofelone in the management of osteoarthritis

Figures & data

Figure 1 Actions of eicosanoids: from the enzymes to the main effects through the superfamily of metabolic products (simplified pathway) Copyright © 2002. Modified with permission from Bertolini A, Ottani A, Sandrini M. 2002. Selective COX-2 inhibitors and dual acting anti-inflammatory drugs: critical remarks. Curr Med Chem, 9:1033–43.

Figure 2 Effect of COX-1 and COX-2 inhibition on mechanisms involved in CHD pathogenesis Copyright © 2000. Modified with permission from Whelton 2000.

Abbreviations: COX, cyclooxygenase; LOX, lipoxygenase; PGI, prostaglandin; TxA, thromboxane A.

Abbreviations: COX, cyclooxygenase; LOX, lipoxygenase.

Figure 2 Effect of COX-1 and COX-2 inhibition on mechanisms involved in CHD pathogenesis Copyright © 2000. Modified with permission from Whelton 2000.

Abbreviations: COX, cyclooxygenase; LOX, lipoxygenase; PGI, prostaglandin; TxA, thromboxane A.

Table 1 Therapeutic potentialities of licofelone

Effects of licofelone from preclinical data Anti-inflammatory Analgesic Antipyretic Antiplatelet

Effects in vitro Suppression of the PMN leukocyteplatelet transcellular metabolism of arachidonic acid Prevention of PMN aggregation and activation Reduction of PMN and platelet adhesion

Effects in animal models Reduction of erythema and oedema in osteoarthritis Reduction of synovial cell proliferation Reduction of bone/cartilage erosion

Abbreviations: PMN, polymorphonuclear.

BertoliniAOttaniASandriniM2002Selective COX-2 inhibitors and dual acting anti-inflammatory drugs: critical remarksCurr Med Chem910334312733982

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