Long-term management of GERD in the elderly with pantoprazole

Figures & data

Table 1 Rates of long-term PPIs use

References	Country	Definition	Population size
Ryder et al 1994 Chen et al 2003	UK	Six months or more	60 148
Roberts and Bateman 1995	UK	All PPI prescribing in a defined period	41 GP practices
Rubin et al 1995	UK	>12 months	24 400
Goudie et al 1996	UK	Repeat prescribing register	15 495
Boutet et al 1999	Sicily, UK	Repeat prescribing register	42 GP practices
Hungin et al 1999	UK	6 months or more	46 650
Prach et al 1999 Roberts and Bateman 1995	UK	More than 56 days/year	35 000
Vetvick and Straand 2001 Jacobson et al 2003	Norway	ddu	17 105
Ahnfeldt-Mollerup et al 1997	Denmark	Constant treatment	7160
Hurenkamp et al 2002 Tsai et al 2004	Holland	More than 12 weeks	46 813
Chen et al 2003	Taiwan	Prescription items and ddu	/
Jacobson et al 2003	USA	More than 90 days	168 727
Raghunath and Hungin 2004	UK	Six months or more	46 933
Lassen et al 2004	Denmark	>180 ddu/year	470 000
Majumdar et al 2003	USA	Equal to or more one year	216 720

Abbreviations: ddu, daily defined units; GP, general practitioner; PPIs, proton pump inhibitors.

Table 2 Effects of pantoprazole when co-administered with other drugs

Drug	Pantoprazole
Carbamazepine (Tegretol)	None
Clarithromycin (Biaxin)	Unknown
Diazepam (Valium)	None
Digoxin	> Absorpition
Ketoconazole (Nizoral)	Unknown
Methotrexate	Unknown
Nifedipine (Procardia)	> Absorption
Oral contraceptives	None
Phenytoin (Dilantin)	None
Warfarin (Coumadin)	None
Theophylline	None

RyderSDO’ReillySMillerRJ1994Long term acid suppressing treatment in general practiceBMJ308827308167491

 PubMed Web of Science ®Google Scholar

ChenTJChouLFHwangSJ2003Trends in prescribing proton pump inhibitors in Taiwan: 1Int J Clin Pharmacol Ther412071212776811

 PubMed Web of Science ®Google Scholar

RobertsSJBatemanDN1995Prescribing of antiacids and ulcer healing drugs in primary care in the north of EnglandAliment Pharmacol Ther9137437605853

 PubMed Web of Science ®Google Scholar

RubinGPContractorBBrambleMG1995The use of long term acid-suppression therapyBr J Clin Pract49119207779658

 PubMedGoogle Scholar

GoudieBMMcKenziePECiprianoJ1996Repeat prescribing of ulcer healing drugs in general practice-prevalence and underlying diagnosisAliment Pharmacol Ther10147508730242

 PubMed Web of Science ®Google Scholar

BoutetRWilcockMMackenzieI1999Survey on repeat prescribing for acid suppression drugs in primary care in Cornwall and the isles of SicilyAliment Pharmacol Ther138131710383512

 PubMed Web of Science ®Google Scholar

HunginAPRubinGO’FlanaganH1999Factors influencing compliance in long-term proton pump inhibitor therapy in general practiceBr J Gen Pract49463410562747

 PubMed Web of Science ®Google Scholar

PrachATMcGilchristMMMurrayFE1999Prescription of acid suppressing drugs in relation to endoscopic diagnosis: a record-linkage studyAliment Pharmacol Ther1339740510102974

 PubMed Web of Science ®Google Scholar

VetvikKStraandJ2001Acid-related disease in the population of two Norwegian municipalities—diagnosis and drug therapyTidsskr Nor Laegeforen1215576211301609

 PubMedGoogle Scholar

JacobsonBCFerrisTGSheaTL2003Who is using chronic acid suppression therapy and why?Am J Gastroenterol9851812526936

 PubMed Web of Science ®Google Scholar

Ahnfeldt-MollerupIFlyGFKnudsenMH1997Dyspepsia in general practice. A study among users of anti-ulcer agentsUgeskr Laeger159377269214053

 PubMedGoogle Scholar

HurenkampGJGrundmeyerHGBindelsPJ2002How do primary care physicians use long-term acid suppressant drugs? A population-based analysis of Dutch general practicesJ Fam Pract51241511978235

 PubMed Web of Science ®Google Scholar

TsaiHHChapmanRShepherdA2004Esomeprazole 20 mg on-demand is more acceptable to patients than continuous lansoprazole 15 mg in the long-term maintenance of endoscopy-negative gastro-oesophageal reflux patients: the COMMAND StudyAliment Pharmacol Ther206576515352914

 PubMed Web of Science ®Google Scholar

RaghunathASHunginAPS2004Long-term prescribing of proton pump inhibitors in primary care: a cross-sectional surveyGut53suppl. 1A24

 Google Scholar

LassenAHallasJSchaffalitzky De MuckadellOB2004Use of anti-secretory medication: a population-based cohort studyAliment Pharmacol Ther205778315339329

 PubMed Web of Science ®Google Scholar

MajumdarSRSoumeraiSBFarrayeFA2003Chronic acid-related disorders are common and under investigatedAm J Gastroenterol9824091414638341

 PubMed Web of Science ®Google Scholar