Antihypertensive drugs and erectile dysfunction as seen in spontaneous reports, with focus on angiotensin II type 1 receptor blockers

Figures & data

Table 1 Summary of 59 spontaneously reported cases of erectile dysfunction submitted to the Swedish Medical Products Agency between 1990 and 2006 and where at least one antihypertensive drug was suspected to have caused the reaction

	Total number of reports N	Reports with concomitant antihypertensive medication N (%)	Age years median (range)	Time to onset median (range)	Positive dechallenge N (%)	Indication hypertension N (%)	Diabetes^1 N (%)
Beta blocking agents	12	2 (17%)^2	55 years (31–77)	7 months (weeks–4 years)	7 (58%)	6 (50%)	0
Calcium channel blockers	23	10 (43%)^3	53 years (34–70)	Days (1 day–3 years)	20 (87%)	20 (87%)	2 (9%)
ACE inhibitors	11	0	58 years (39–63)	5 months (9 days–2 years)	9 (82%)	7 (64%)	2 (18%)
Angiotensin II receptor antagonists	9	2 (22%)^4	53 years (41–75)	2 weeks (1 week–10 months)	5 (56%)	6 (67%)	0
Thiazide diuretics	5	1 (20%)^5	65 years (60–72)	1 month (1 day–14 months)	3 (60%)	4 (80%)	0

1 Diabetes mentioned in the narratives or use of antidiabetic medication was described in the report;

2 One subject had a thiazide diuretic and 1 subject had an angiotensin II receptor antagonists as concomitant medication;

3 Two subjects had a thiazide diuretic, 4 subjects beta-antagonists, and 4 subjects ACE inhibitors as concomitant medications;

4 One subject had a thiazide diuretic and one subject a beta-antagonist as concomitant medications;

5 One subjects had a beta-agonist as a concomitant medication.

Table 2 Observed and expected number of reports of ED and corresponding IC values with 95% confidence limits, sales and reports per million DDD-years

	Number of reports N (expected)	IC value	IC 95% confidence limits	Sales (million DDD-years)	Reports/million DDD-years
Beta-antagonists	12 (2.8)	1.9	1.0–2.6	7.5	1.6
Calcium channel blockers	23 (4.0)	2.4	1.8–2.9	5.0	4.6
ACE inhibitors	11 (7.1)	0.6	−0.4–1.3	5.6	2.0
Angiotensin II receptor antagonists	9 (2.1)	1.9	0.8–2.7	1.3	6.7
Thiazide diuretics	5 (0.4)	2.7	1.2–3.7	1.7	2.9

Notes: 1 DDD-year = 365 DDDs.

Abbreviations: IC, information component; DDD, defined daily doses.