Figures & data
Figure 1 Structure of sitagliptin.
Figure 2 24-hour plasma glucose profile in patients with type 2 diabetes after four weeks treatment with sitagliptin (100 mg daily) added to ongoing treatment with metformin compared to patients continued with metformin alone. Reproduced with permission from Brazg R, Xu L, Dalla Man C, et al. Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes. Diabet Obes Metab. 2007; 9:186–193.Citation25 Copyright © 2007 Wiley-Blackwell.
Figure 3 Mean HbA1c, mean body weight and percentage of patients with at least one event of hypoglycemia during 52 weeks treatment with sitagliptin (100 mg daily) or glipizide as add-on to metformin in patients with type 2 diabetes. Reproduced from Nauck MA, Meininger G, Sheng D, Terranella L, Stein PP. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, doubleblind, non-inferiority trial. Diabet Obes Metab. 2007; 9:194–205.Citation54 Copyright © 2007 Wiley-Blackwell.
Figure 4 Changes in HbA1c during 24–26 weeks treatment with four different DPP-4 inhibitors in clinical trials, as monotherapy or as add-on to metformin, a thiazolidinedione (TZD) or a sulfonylurea (SU). Baseline HbA1c levels above column.
