The use of anti-tuberculosis therapy for latent TB infection

Figures & data

Table 1 Dosing regimens for tuberculosis

Drug/dose	Frequency/duration	Rating (evidence)
		HIV negative	HIV positive
Preferred Regimen
Isoniazid	Daily × 9 months	A (II)	A (II)
Adult: 5 mg/kg
Children: 10–20 mg/kg
Maximum dose 300 mg
Alternate Regimens
Isoniazid	Twice weekly × 9 months	B (II)	B (II)
Adult: 15 mg/kg
Children: 20–40 mg/kg
Maximum dose 900 mg
Isoniazid	Daily × 6 months	B (I)	C (I)
Adults: 5 mg/kg
Maximum dose 300 mg
Isoniazid	Twice weekly × 6 months	B (II)	C (I)
Adults: 15 mg/kg
Maximum dose 900 mg
Rifampin	Daily × 4 months	B (II)	B (II)
Adults: 10 mg/kg
Children: 10–20 mg/kg
Maximum dose 600 mg

Notes: Reproduced from: Centers for Disease Control and Prevention. Guide for Primary Health Care Providers: Targeted tuberculin testing and treatment of latenttuberculosis infection. CDC, 2005. Available at www.cdc.gov/tb/publications/LTBI/intro.htm