A genetic study of the NOS3 gene for ischemic stroke in a Chinese population

Figures & data

Table 1 The general information of patients and controls

	Patients with ischemic stroke
	Controls (n = 153)	Large-vessel (n = 246)	Lacunar (n = 426)	Mixed (n = 112)
Age (y)	55.6 ± 5.7	58.2 ± 12.4	60.5 ± 10.8	60.4 ± 11.5
Men	93	170	303	75
BMI (kg/m^2)	24.9 ± 3.3	24.3 ± 3.2	25.1 ± 3.6	24.8 ± 3.6
History of hypertension	45	152	301	79
History of diabetes	16	44	80	21
History of heart disease	19	32	60	12
History of smoking	22	86	141	36

Table 2 Allelic association of the NOS3 gene with ischemic stroke

Group	Allele	Patients (%)	Controls (%)	X^2	P-value
Male
	A	279 (35.1)	51 (27.4)
	G	517 (64.9)	135 (72.6)	4.04	0.044a
Female
	A	107 (33.0)	36 (30.0)
	G	217 (67.0)	84 (70.0)	0.37	0.543
Total
	A	386 (34.5)	87 (28.4)
	G	734 (65.5)	219 (71.6)	4.02	0.045b

Notes:

a OR = 1.428 (95% CI 1.009–2.021);

b OR = 1.324 (95% CI 1.006–1.742).

Table 3 Genotypic association of the NOS3 gene with ischemic stroke

Group	Genotype	Patients (%)	Controls (%)	X^2	P-value
Male
	AA + AG	231 (58.1)	43 (46.2)
	GG	167 (42.0)	50 (53.8)	4.25	0.039a
Female
	AA + AG	90 (55.6)	30 (50.0)
	GG	72 (44.4)	30 (50.0)	0.54	0.461
Total
	AA + AG	321 (57.3)	73 (47.7)
	GG	239 (42.7)	80 (52.3)	4.49	0.034b

Notes:

a OR = 1.608 (95% CI 1.022∼2.532);

b OR = 1.472 (95% CI 1.028∼2.107).