Preliminary effects of pagoclone, a partial GABA_A agonist, on neuropsychological performance

Figures & data

Table 1 Change from baseline for all subjects: main effect of day

Test	Day
	Day 1	Day 6	F	p<
Stanford Sleepiness	0.79	−0.07	7.82	0.007
Buschke Selective Reminding
Immediate Recall	−2.80	0.34	2.68	0.108
Long Term Storage (LTS)	−7.63	−0.21	4.73	0.035
Delayed Recall	−1.80	−0.02	8.11	0.006
Motor Screen Latency	−37.90	−46.17	0.07	0.798
RVP
A’	0.00	0.02	8.27	0.006
Mean Latency	2.21	−38.84	12.22	0.001
Simple Reaction Time
Reaction Time	−13.07	−17.07	0.84	0.364
Movement Time	−17.06	−23.50	0.16	0.690
Choice Reaction Time
Reaction Time	−2.13	−5.05	0.20	0.657
Movement Time	−5.93	−7.26	0.00	0.959
Digit Symbol Test	0.07	4.82	9.96	0.003

Note: All scores have been adjusted with age as a covariate.

Table 2 Change from baseline for all subjects: main effect of dose

Test	Dose
	0.15 mg	0.30 mg	0.60 mg	F	p<
Stanford Sleepiness	−0.14	0.94	0.27	4.20	0.021
Buschke Selective Reminding
Immediate Recall	2.47	−1.45	−4.70	4.68	0.014
Long Term Storage (LTS)	3.70	−6.00	−9.46	5.34	0.008
Delayed Recall	−0.18	−0.43	−2.10	3.71	0.032
Motor Screen Latency	−80.61	−43.73	−1.77	2.01	0.145
RVP
A’	0.01	0.00	0.01	1.55	0.223
Mean Latency	−11.98	−23.07	−19.90	0.31	0.731
Simple Reaction Time
Reaction Time	−17.56	−18.81	−8.85	2.06	0.138
Movement Time	−44.60	−9.22	−7.02	2.30	0.111
Choice Reaction Time
Reaction Time	−3.13	−9.97	2.32	1.18	0.315
Movement Time	−53.22	26.86	6.57	3.46	0.039
Digit Symbol Test	4.22	2.76	0.35	2.25	0.116

Note: All scores have been adjusted with age as a covariate.