Management of obsessive-compulsive disorder with fluvoxamine extended release

Figures & data

Table 1 Comparison between the pharmacokinetic parameters of IR and CR formulations of fluvoxamine

	Fluvoxamine IR	Fluvoxamine CR
Bioavailability
Tmax	6 h	15 h
Cmax	41.88 ng/mL (±18.99)	25.78 ng/mL (±15.66)
AUC(0–inf)	959.33 ng × h/mL (±520.71)	806.31 ng × h/mL (±450.92)
Volume of distribution	25 L/kg	25 L/kg
Plasma protein-binding	80%	80%
Metabolism	Deamination and oxidative demethylation	Deamination and oxidative demethylation
Plasma half-life	15.9 h	16.3 h
Excretion	Renal	Renal

Abbreviations: IR, immediate release; CR, extended release; T_max, time to maximum plasma concentration; C_max, maximum plasma concentration; AUC _(0–inf), area under the curve.