Pregabalin in the management of partial epilepsy

Figures & data

Table 1 Summary of randomized, double-blind, placebo-controlled trials with pregabalin

Author	Doses used (mg/day)	Seizure responder rate (%)	Discontinuation rate (%)	Most common side effects
French^Citation15	50, 150, 300, 600 in BID doses	15, 31, 40, 51	7, 1.2, 14, 24	Somnolence, dizziness
Arroyo^Citation16	150, 600 in TID doses	14.1, 43.5	10, 18.5	Dizziness, somnolence
Beydoun^Citation17	600 in BID vs TID doses	43, 49	26, 19	Dizziness, somnolence
Elger^Citation18	600 in BID vs 150 600 flexible dose	45.3, 31.3	33, 12	Dizziness, ataxia

Abbreviations: BID, given in two divided doses; TID, given in three divided doses.

FrenchJAKuglerARRobbinsJLKnappLEGarofaloEADose-response trial of pregabalin adjunctive therapy in patients with partial seizuresNeurology200360101631163712771254

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ArroyoSAnhutHKuglerARPregabalin add-on treatment: a randomized, double-blind, placebo-controlled, dose-response study in adults with partial seizuresEpilepsia2004451202714692903

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BeydounAUthmanBMKuglerARGreinerMJKnappLEGarofaloEASafety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsyNeurology200564347548015699378

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ElgerCEBrodieMJAnhutHLeeCMBarrettJAPregabalin add-on treatment in patients with partial seizures: a novel evaluation of flexible-dose and fixed-dose treatment in a double-blind, placebo-controlled studyEpilepsia200546121926193616393158

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