Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder

Figures & data

Table 1 Basal and 10 μM ISO-stimulated adenylate cyclase activity in platelet membranes from healthy subjects and OCD patients

	Basal AC	+ ISO 10 μM
Healthy subjects	14.00 ± 1.72	20.61 ± 2.50
OCD patients	13.60 ± 1.59	22.99 ± 3.48

Note: Data are presented as mean ± SEM of n experiments each performed in duplicate.

Abbreviation: ISO, isoprenaline.

Figure 1 Isoprenaline dose-response curve in one OCD patient and control subject.

Abbreviation: ISO, isoprenaline

Table 2 ISO stimulation parameters measured in platelet membranes of healthy subjects and OCD patients

	EC50(nM)	Emax (%)
Healthy subjects	85.62 ± 18.82	151.70 ± 4.40
OCD patients	53.80 ± 23.26*	177.40 ± 9.51**

Notes: Data are presented as mean ± SEM of 3 experiments each performed in duplicate.

* significant, t = 4.78, p = 0.01.

** significant, t = 6.46, p = 0.01.

Abbreviation: ISO, isoprenaline.

Figure 2 Dose-response curve of isoprenaline alone and in the presence of rauwolscine, propanolol and both the compounds.

Abbreviation:ISO, isoprenaline