Figures & data
Table 1 Principal placebo-controlled trials of antidepressants in the treatment of fibromyalgia syndrome
CaretteSMcCainGABellDA1986Evaluation of amitriptyline in primary fibrositis. A double-blind, placebo-controlled studyArthritis Rheum2965593521612 GoldenbergDLFelsonDTDinermanH1986A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgiaArthritis Rheum29137173535811 BibolottiEBorghiCPasculliE1986A double-blind comparison of maprotiline, chloriimipramine and placeboClin Trials J2326980 CarusoISarzi PuttiniPCBoccassiniL1987Double-blind study of dothiepin versus placebo in the treatment of primary fibromyalgia syndromeJ Int Med Res1515493301454 ScuddsRAMcCainGARollmanGB1989Improvements in pain responsiveness in patients with fibrositis after successful treatment with amitriptylineJ Rheumatol Suppl19981032481743 JaeschkeRAdachiJGuyattG1991Clinical usefulness of amitriptyline in fibromyalgia: the results of 23 N-of-1 randomized controlled trialsJ Rheumatol18447511856813 CaretteSBellMJReynoldsWJ1994Comparison of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia. A randomized, double-blind clinical trialArthritis Rheum3732408129762 WolfeFCatheyMAHawleyDJ1994A double-blind placebo controlled trial of fluoxetine in fibromyalgiaScand J Rheumatol232552597973479 NorregaardJVolkmannHDanneskiold-SamsoeB1995A randomized controlled trial of citalopram in the treatment of fibromyalgiaPain6144597478688 GinsbergFMancauxAJoosE1996A randomised placebo-controlled trial of sustained release amitriptyline in primary fibromyalgiaJ Muscoskeletal Pain43747 GoldenbergDMayskiyMMosseyC1996A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgiaArthritis Rheum39185218598912507 HannonenPMalminiemiKYli-KerttulaU1998A randomized, double-blind, placebo-controlled study of moclobemide and amitriptyline in the treatment of fibromyalgia in females without psychiatric disorderBr J Rheumatol371279869973149 AnderbergUMMarteinsdottirIvon KnorringL2000Citalopram in patients with fibromyalgia— a randomized, double-blind, placebo-controlled studyEur J Pain4273510833553 ArnoldLMHessEVHudsonJI2002A randomized, placebo-controlled, double-blind, flexible-dose study of fluoxetine in the treatment of women with fibromyalgiaAm J Med112191711893345 ZijlstraTRBarendregtEJvan de LaarMA2002Venlafaxine in fibromyalgia: results of a randomized, placebo-controlled, double-blind trialArthritis Rheum46suppl 9S105 PurcellCPatkarAMasandP2004Predictors of response to placebo-controlled, double-blind trial of paroxetine controlled release in fibromyalgiaProgram and abstracts of the American Psychiatric Association Annual Meeting51–62004New York, NY Abstract NR361 ArnoldLMHudsonJIHessEV2004aFamily study of fibromyalgiaArthritis Rheum509445215022338 ArnoldLMRosenAPritchettYL2005A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorderPain11951516298061 GendreauRMThornMDGendreauJF2005Efficacy of milnacipran in patients with fibromyalgiaJ Rheumatol3219758516206355