The cytotoxic effects of lipidic formulated gold porphyrin nanoparticles for the treatment of neuroblastoma

Figures & data

Figure 1 Size characterization by transmission electron microscopy (TEM) of A) free gold porphyrin, or B) lipidic gold porphyrin nanoparticles. The scale bar represents 20 nm or 0.5 μm.

Table 1 IC₅₀ values of 6 neuroblastoma cell lines N2A, CHP-212, Be(2)-C, SH-SY5Y, LAN-1, and LAN-2 treated with either free gold porphyrin nanoparticles (Free GP) or lipidic gold porphyrin nanoparticles (Lipidic GPNP)

Cell lines	Lipidic GPNP mg/ml	Free GP mg/ml
N2A	0.013	0.0032
CHP-212	0.0075	0.0007
Be(2)-C	0.003	0.0006
SH-SY5Y	0.003	0.0012
LAN-1	0.0037	0.0076
LAN-2	0.0034	0.0067

Figure 2 The effect of lipidic gold porphyrin nanoparticles on survival rate of normal A/J mice having received either free gold porphyrin nanoparticles or lipidic gold porphyrin nanoparticles. Data was represented in percentage of survival. GP represents free gold porphyrin nanoparticles while GPNP represents lipidic gold porphyrin nanoparticles. (n = 6).

Figure 3 The therapeutic efficiency of lipidic gold porphyrin nanoparticles in neuroblastoma bearing mice. A) tumor volume measurements after tumorbearing mice received intraperitonal injection of 0.08 mg or 0.1 mg of lipidic gold porphyrin nanoparticles. (n = 5–6, *P < 0.05). B) the effect of lipidic gold porphyrin nanoparticles on survival rate. (n = 6).