Clinical investigation of the effect of topical anesthesia on intraocular pressure

Figures & data

Table 1 Age and IOP characteristics of subject groups

	Age	IOP before drops	2 mins after	5 mins after
Refresh (Control)
Eyedrops
Average	21.0	15.1	15.3	15.1
Std Dev	2.0	2.6	2.5	2.5
p values			p > 0.05	p > 0.05
Novesin
Eyedrops
Average	21.1	15.7	15.1	14.9
Std Dev	2.0	3.6	3.1	3.0
p values			p < 0.01	p < 0.001
Alcaine
Eyedrops
Average	21.4	16.1	15.3	15.1
Std Dev	1.9	3.0	3.2	3.0
p values			p < 0.001	p < 0.001

p values are from repeated-measures ANOVA comparisons of IOP 2 minutes and 5 minutes after eyedrop instillation, with the baseline IOP measured before the eyedrop was instilled.

Table 2 Effect of 0.5% carboxymethylcellulose sodium on IOP – number of subjects (% of total subjects)

Change in IOP	2 minutes post-eyedrop instillation	5 minutes post-eyedrop instillation
2 mmHg increase	3 (7.5%)	3 (7.5%)
1 mmHg increase	15 (37.5%)	7 (17.5%)
No Change	10 (25%)	20 (50%)
1 mmHg decrease	10 (25%)	8 (20%)
2 mmHg decrease	2 (5%)	1 (2.5%)
3 mmHg decrease	0 (0%)	1 (2.5%)

Table 3 Effect of 0.4% oxybuprocaine hydrochloride on IOP – number of subjects (% of total subjects)

Change in IOP	2 minutes post-eyedrop instillation	5 minutes post-eyedrop instillation
2 mmHg increase	2 (5%)	3 (7.5%)
1 mmHg increase	7 (17.5%)	3 (7.5%)
No Change	5 (12.5%)	7 (17.5%)
1 mmHg decrease	15 (37.5%)	13 (32.5%)
2 mmHg decrease	10 (25%)	12 (30%)
3 mmHg decrease	1 (2.5%)	2 (5%)

Table 4 Effect of 0.5% proparacaine hydrochloride on IOP – number of subjects (% of total subjects)

Change in IOP	2 minutes post-eyedrop instillation	5 minutes post-eyedrop instillation
3 mmHg increase	1 (2.5%)	1 (2.5%)
2 mmHg increase	0 (0%)	1 (2.5%)
1 mmHg increase	9 (22.5%)	2 (5%)
No Change	1 (2.5%)	6 (15%)
1 mmHg decrease	17 (42.5%)	16 (40%)
2 mmHg decrease	8 (20%)	10 (25%)
3 mmHg decrease	4 (10%)	4 (10%)