Differences in optic nerve structure between individuals of predominantly African and European ancestry: Implications for disease detection and pathogenesis

Figures & data

Figure 1a Proportion of African Ancestry as determined from polymorphisms within 178 AIMs for normal self-described black ADAGES participants (n = 45).

Figure 1b Mean (±standard deviation) percentage Ancestry in the four Ancestral Groups determined by polymorphisms within 178 AIMS for normal Self-described black ADAGES participants (n = 45).

Table 1 Comparison of structural parameters of the optic disc between African-American and White groups

CSLO Parameter	White n = 53 Mean (se)	Black n = 73 Mean (se)	p-valueº	p-value†	p-value‡
Ratio parameters
Cup disc area ratio	0.1911 (0.014)	0.2442 (0.012)	0.0130	0.0776	0.1270
Vertical cup-to-disc ratio	0.2682 (0.023)	0.3346 (0.018)	0.0398	0.1606	0.1973
Cup related parameters
Cup area (mm^2)	0.3917 (0.031)	0.5582 (0.034)	0.0016*	0.0604	0.1179
Cup volume (mm^3)	0.0812 (0.009)	0.1370 (0.014)	0.0019*	0.0339	0.0327
Mean cup depth (mm)	0.1770 (0.009)	0.2270 (0.008)	0.0002*	0.0031*	0.0090
Maximum cup depth (mm)	0.4928 (0.023)	0.6235 (0.016)	<0.0001*	0.0011*	0.0039*
Cup shape measure	−0.1878 (0.007)	−0.1856 (0.007)	0.4357	0.8565	0.7914
Rim related parameters
Rim area (mm^2)	1.5983 (0.037)	1.6007 (0.027)	0.8402	0.0606	0.1183
Rim volume (mm^3)	0.4477 (0.018)	0.4597 (0.014)	0.5095	0.8186	0.3161
Disc margin related parameters
Mean RNFL thickness (mm)	0.2488 (0.007)	0.2774 (0.006)	0.0120	0.0109	0.3482
CLM temporal to superior (mm)	0.1916 (0.008)	0.2323 (0.007)	0.0029*	0.0086	0.1166
CLM temporal to inferior (mm)	0.1820 (0.009)	0.2034 (0.007)	0.0876	0.1044	0.4349
Maximum contour depression (mm)	0.2545 (0.015)	0.3077 (0.012)	0.0076	0.0257	0.3636

* Significant p-value, Bonferroni p-value <0.0042.

° Unadjusted.

† Adjusted for disc area.

‡ Adjusted for disc area and reference height.

Modified from: Girkin CA, McGwin G, Jr., Xie A, Deleon-Ortega J. Differences in optic disc topography between black and white normal subjects. Ophthalmology. 2005;112:33–9.